Timosaponin A3 (A-III)

INCI: NOT ASSIGNED A FORMAL INCI NAME โ€” TYPICALLY LISTED AS ANEMARRHENA ASPHODELOIDES ROOT EXTRACT (WHEN USED AS BOTANICAL SOURCE)

CAS Number
41059-79-4
Function
Anti-wrinkle agent, MMP-1 inhibitor, photoprotective, skin conditioning
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes No specific restriction; permitted under general cosmetic provisions; no CIR review as isolated compound

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Hepatotoxicity via ROS generation and bile acid transporter suppression at pharmacological doses ; ensure topical-only use at low concentrations; no formal SCCS or CIR opinion

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Concern Level: High

Frequently Asked Questions

Is Timosaponin A3 (A-III) safe in cosmetics?

Hepatotoxicity via ROS generation and bile acid transporter suppression at pharmacological doses ; ensure topical-only use at low concentrations; no formal SCCS or CIR opinion The EU classifies Timosaponin A3 (A-III) as "permitted". Safety rating: MODERATE.

Is Timosaponin A3 (A-III) allowed in the EU?

Timosaponin A3 (A-III) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Timosaponin A3 (A-III) do in cosmetics?

Timosaponin A3 (A-III) functions as: Anti-wrinkle agent, MMP-1 inhibitor, photoprotective, skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 41059-79-4.

What is the Margin of Safety for Timosaponin A3 (A-III)?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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