Excellent Cosmetic Ingredient NOAEL Data

Tributyl Citrate

INCI: TRIBUTYL CITRATE

CAS Number
77-94-1
Function
Film-forming, plasticizer, solvent, hair conditioning, stabilizing
Safety Rating
EXCELLENT

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted; GRAS as indirect food additive; CIR assessed safe

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for Tributyl Citrate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL >=1000 mg/kg bw/day oral rat oral REACH

Expert Verdict

Higher concentrations may cause mild irritation on very sensitive skin; serves as phthalate-free plasticizer alternative

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Concern Level: Low

Frequently Asked Questions

Is Tributyl Citrate safe in cosmetics?

Higher concentrations may cause mild irritation on very sensitive skin; serves as phthalate-free plasticizer alternative The EU classifies Tributyl Citrate as "permitted". Safety rating: EXCELLENT. 1 toxicological study endpoint(s) are available in our database.

Is Tributyl Citrate allowed in the EU?

Tributyl Citrate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Tributyl Citrate do in cosmetics?

Tributyl Citrate functions as: Film-forming, plasticizer, solvent, hair conditioning, stabilizing. It is classified as a cosmetic ingredient in our database. CAS number: 77-94-1.

What is the Margin of Safety for Tributyl Citrate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Tributyl Citrate?

The NOAEL (No Observed Adverse Effect Level) for Tributyl Citrate is >=1000 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.

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