Is TRIMELLITIC ANHYDRIDE safe in cosmetics?
TRIMELLITIC ANHYDRIDE has a safety rating of "GOOD" in our database. EU status: permitted.
TRIMELLITIC ANHYDRIDE
Also known as: 1,2,4-Benzenetricarboxylic anhydride, 5-Isobenzofurancarboxylic acid, 1,3-dihydro-1,3-dioxo-, 5-18-08-00562, Anhydride-ethomid ht polymer, BRN 0009394 (+13 more)
TRIMELLITIC ANHYDRIDE (CAS 552-30-7) is a cosmetic cosmetic ingredient functioning as Not Reported. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 552-30-7 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
TRIMELLITIC ANHYDRIDE is classified GHS Danger (H317, H318, H334, H335, H303, H316, H370, H372) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Not Reported
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
1,3-dioxo-2-benzofuran-5-carboxylic acid
InChIKey
SRPWOOOHEPICQU-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is severely irritating to the eyes. The substance is irritating to the skin and respiratory tract. Inhalation of dust may cause asthma-like reactions.
Long-term Exposure Effects
Repeated or prolonged inhalation may cause asthma. The substance may cause allergic reactions with flu-like symptoms and 'pulmonary disease-anaemia syndrome'.
Routes of Exposure
The substance can be absorbed into the body by inhalation and by ingestion.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
Harmful / IrritantCorrosiveHealth Hazard
Hazard Class and Category
STOT SE 3; Eye Dam. 1; Resp. Sens. 1; Skin Sens. 1
Hazard Statements
- H335 May cause respiratory irritation
- H318 Causes serious eye damage
- H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled
- H317 May cause an allergic skin reaction
Inserted via ATP: CLP00
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
DPRA Cys %
-1.1%
DPRA Lys %
43.7%
KeratinoSens IC50
2000 µM
hCLAT CV75
250 µg/mL
LLNA EC3
9.2%
NESIL
2300 µg/cm²
LLNA: Moderate (1B)
GHS: 1B
Source: LLNA: Gerberick et al. (2005); DPRA: Gerberick et al. 2007 [DOI:10.1093/toxsci/kfm064]; KS: Joint Research Centre of the European Union 2014; hCLAT: Ashikaga et al. 2010 [DOI:10.1177/026119291003800403]
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10,000 - 100,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
Yes (since 27-Jun-2018)
Hazard classification: Restricted (Annex XVII)
SVHC reason: Respiratory sensitising properties (Article 57(f) - human health)
Substance of Very High Concern (SVHC)
Included: 27-Jun-2018
Respiratory sensitising properties (Article 57(f) - human health)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
ICSC Safety Card
0345
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
The substance is irritating to the skin, the respiratory tract and is severely irritating to the eyes...
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
No specific technical function
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for TRIMELLITIC ANHYDRIDE.
Regulatory Flags
cosing-sourced
eu-permitted
needs-enrichment
Known Synonyms
1,2,4-Benzenetricarboxylic anhydride
5-Isobenzofurancarboxylic acid, 1,3-dihydro-1,3-dioxo-
5-18-08-00562
Anhydride-ethomid ht polymer
BRN 0009394
Diphenylmethane-4,4'-diisocyanate-trimellic anhydride-ethomid HT polymer
EINECS 209-008-0
NCI-C56633
5-Phthalanacarboxylic acid, 1,3-dioxo-
Trimellic acid anhydride
UNII-80T61EUU7H
1,2,4-Benzenetricarboxylic acid anhydride
1,3-Dioxo-5-phthalancarboxylic acid
Anhydrotrimellic acid
Benzene-1,2,4-tricarboxylic-1,2-anhydride
TMA
TMAN
Trimellic acid 1,2-anhydride
Chemical Function
No specific technical function
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
CEDI
Indirect additives food contact (10/2018)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL2137687
Frequently Asked Questions
Is TRIMELLITIC ANHYDRIDE allowed in the EU?
TRIMELLITIC ANHYDRIDE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does TRIMELLITIC ANHYDRIDE do in cosmetics?
TRIMELLITIC ANHYDRIDE functions as: Not Reported. It is classified as a cosmetic ingredient in our database. CAS number: 552-30-7.
Is TRIMELLITIC ANHYDRIDE used outside cosmetics?
TRIMELLITIC ANHYDRIDE also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does TRIMELLITIC ANHYDRIDE have different safety status in cosmetics vs industrial chemicals?
TRIMELLITIC ANHYDRIDE is classified GHS Danger (H317, H318, H334, H335, H303, H316, H370, H372) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check TRIMELLITIC ANHYDRIDE compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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