Good Cosmetic Ingredient NOAEL Data

Valeriana Officinalis Rhizome/Root

INCI: VALERIANA OFFICINALIS RHIZOME/ROOT

CAS Number
8057-49-6
Function
Skin Conditioning, Fragrance
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted for cosmetic use; also GRAS for food use

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

4 study endpoints found for Valeriana Officinalis Rhizome/Root. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 18600 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
NOAEL 3100 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
dose_tested 18600 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
dose_tested 3100 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB

Expert Verdict

Whole/powdered plant part โ€” safety assessment should specify extraction solvent and particle size

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Concern Level: Low

Regulatory Flags

fragrance-component natural-origin fda_food_additive

Frequently Asked Questions

Is Valeriana Officinalis Rhizome/Root safe in cosmetics?

Whole/powdered plant part โ€” safety assessment should specify extraction solvent and particle size The EU classifies Valeriana Officinalis Rhizome/Root as "permitted". Safety rating: GOOD. 4 toxicological study endpoint(s) are available in our database.

Is Valeriana Officinalis Rhizome/Root allowed in the EU?

Valeriana Officinalis Rhizome/Root EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Valeriana Officinalis Rhizome/Root do in cosmetics?

Valeriana Officinalis Rhizome/Root functions as: Skin Conditioning, Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 8057-49-6.

What is the Margin of Safety for Valeriana Officinalis Rhizome/Root?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Valeriana Officinalis Rhizome/Root?

The NOAEL (No Observed Adverse Effect Level) for Valeriana Officinalis Rhizome/Root is 18600 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 4 study endpoints are available. Source: COSMOS_DB.

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