Is Veratrole safe in cosmetics?
Veratrole has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Veratrole
Also known as: EINECS 202-045-3, FEMA No. 3799, 2-Dimethoxybenzol, Brenzkatechindimethylether, Synthol (+4 more)
INCI: VERATROLE
Veratrole (CAS 91-16-7) is a cosmetic cosmetic ingredient functioning as Perfuming (fragrance ingredient). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 91-16-7 →
Auto-generated CPSR Part A draft with source citations
Function
Perfuming (fragrance ingredient)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
1,2-dimethoxybenzene
InChIKey
ABDKAPXRBAPSQN-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted for cosmetic use; FEMA GRAS flavoring substance
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Veratrole.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (3)
JECFA Number
1248
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
1,2-DIMETHOXYBENZENE | 2008 | No safety concern at current levels of intake when used as a flavouring agent | ">RS 952-JECFA 69/149 | ">FAS 60-JECFA 69/628
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
CATECHOL DIMETHYL ETHER | 2008 | No safety concern at current levels of intake when used as a flavouring agent | ">RS 952-JECFA 69/149 | ">FAS 60-JECFA 69/628
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Veratrole.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
Known Synonyms
EINECS 202-045-3
FEMA No. 3799
2-Dimethoxybenzol
Brenzkatechindimethylether
Synthol
Dimethylether pyrokatechinu
UNII-61WJZ2Q41I
Methyl guaiacol
O,O-Dimethyl catechol
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
1,2-DIMETHOXYBENZENE
ChEMBL ID
CHEMBL1668603
Frequently Asked Questions
Is Veratrole allowed in the EU?
Veratrole EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Veratrole do in cosmetics?
Veratrole functions as: Perfuming (fragrance ingredient). It is classified as a cosmetic ingredient in our database. CAS number: 91-16-7.
Is Veratrole used outside cosmetics?
Veratrole also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Veratrole compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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