Moderate Cosmetic Ingredient NOAEL Data

Veratrole

INCI: VERATROLE

CAS Number
91-16-7
Function
Perfuming (fragrance ingredient)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted for cosmetic use; FEMA GRAS flavoring substance

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
high
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for Veratrole. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOEL 10 mg/kg bw/day oral rat oral REACH

Expert Verdict

Volatile organic compound. Use within IFRA recommended limits. 1,2-Dimethoxybenzene โ€” structurally simple aromatic ether. Ensure purity specifications are met to avoid unwanted contaminants

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Concern Level: Moderate

Regulatory Flags

fragrance-component ifra_fragrance fda_food_additive

Frequently Asked Questions

Is Veratrole safe in cosmetics?

Volatile organic compound. Use within IFRA recommended limits. 1,2-Dimethoxybenzene โ€” structurally simple aromatic ether. Ensure purity specifications are met to avoid unwanted contaminants The EU classifies Veratrole as "permitted". Safety rating: MODERATE. 1 toxicological study endpoint(s) are available in our database.

Is Veratrole allowed in the EU?

Veratrole EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Veratrole do in cosmetics?

Veratrole functions as: Perfuming (fragrance ingredient). It is classified as a cosmetic ingredient in our database. CAS number: 91-16-7.

What is the Margin of Safety for Veratrole?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Veratrole?

The NOAEL (No Observed Adverse Effect Level) for Veratrole is 10 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.

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