Good Antioxidant Sensitization Data

Vitamin E Oil

INCI: TOCOPHERYL ACETATE

CAS Number
7695-91-2
Function
Antioxidant; stabilized vitamin E ester
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes No FDA cosmetic restrictions. GRAS as food antioxidant/nutrient (21 CFR 182.8892). CIR (2002, updated 2018) safe as used at concentrations up to 36%. VCRP confirms widespread use across product categories.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Sensitization Profile

Contact sensitization data for Vitamin E Oil based on clinical patch test studies and IFRA standards.

Sensitization Rate
low
Allergen Class
botanical
EU Allergen Listed
no
Patch Test Positive Rate
0.3%
Cross-reactivity Group
none
Reaction Type
contact-dermatitis

Source: IVDK; ESSCA; NACDG

Expert Verdict

Tocopheryl Acetate (CAS 7695-91-2) is permitted in the EU without restriction and not listed in Annex II or III of EC 1223/2009. It is GRAS for food use and deemed safe by CIR at concentrations up to 36%.

⚠️
Concern Level: Low

Regulatory Flags

contact-dermatitis-risk rare-sensitizer gras-food cir-reviewed-2018 widely-used eu_children_restricted epa_safer_alternative ifra_fragrance

Frequently Asked Questions

Is Vitamin E Oil safe in cosmetics?

Tocopheryl Acetate (CAS 7695-91-2) is permitted in the EU without restriction and not listed in Annex II or III of EC 1223/2009. It is GRAS for food use and deemed safe by CIR at concentrations up to 36%. The EU classifies Vitamin E Oil as "permitted". Safety rating: GOOD.

Is Vitamin E Oil allowed in the EU?

Vitamin E Oil EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Vitamin E Oil do in cosmetics?

Vitamin E Oil functions as: Antioxidant; stabilized vitamin E ester. It is classified as a Antioxidant in our database. CAS number: 7695-91-2.

What is the Margin of Safety for Vitamin E Oil?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Vitamin E Oil compliance across multiple jurisdictions:

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Ingredient Decoder
Paste a full ingredient list for instant analysis
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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