Is Vitamin E Oil safe in cosmetics?
Vitamin E Oil has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
Vitamin E Oil
Also known as: 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, 6-acetate, 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate, 6-Chromanol, 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-yl acetate, 3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-ylacetat (+8 more)
INCI: TOCOPHERYL ACETATE
Vitamin E Oil (CAS 7695-91-2) is a cosmetic antioxidant functioning as Antioxidant; stabilized vitamin E ester. Reported NOAEL =500 mg/kg bw/day in Rat (ECHA); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and food safety data.
Function
Antioxidant; stabilized vitamin E ester
Editorial assessment
GOOD
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
[2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydrochromen-6-yl] acetate
InChIKey
ZAKOWWREFLAJOT-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No FDA cosmetic restrictions. GRAS as food antioxidant/nutrient (21 CFR 182.8892). CIR (2002, updated 2018) safe as used at concentrations up to 36%. VCRP confirms widespread use across product categories.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Vitamin E Oil.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Vitamin E Oil. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =500 mg/kg bw/day | oral | Rat | subchronic | ECHA |
| NOAEL | =1600 mg/kg bw/day | oral | Hamster | reproduction developmental | ECHA |
Sensitization Profile
Contact sensitization data for Vitamin E Oil based on clinical patch test studies and IFRA standards.
Sensitization Rate
low
Allergen Class
botanical
EU Allergen Listed
no
Patch Test Positive Rate
0.3%
Cross-reactivity Group
none
Reaction Type
contact-dermatitis
Source: IVDK; ESSCA; NACDG
EPA ToxValDB — Toxicity Values
10 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| NOAEL | =540 mg/day | Human | oral | - | EFSA |
| LD50 | >3000 mg/kg | Rat | dermal | acute | ECHA |
| LD50 | >2000 mg/kg | Rabbit | oral | - | ECHA |
| LD50 | >14400 mg/kg | Dog | oral | - | ECHA |
| LD50 | >4000 mg/kg | Mouse | oral | - | ECHA |
| LD50 | >10000 mg/kg | Rat | oral | - | ECHA |
| NOAEL | >2000 mg/kg-day | Rat | oral | - | ECHA |
| NOAEL | =1600 mg/kg-day | Hamster | oral | - | ECHA |
| NOAEL | >1600 mg/kg-day | Rabbit | oral | - | ECHA |
| NOAEL | =1600 mg/kg-day | Mouse | oral | - | ECHA |
Endocrine Disruptor Evidence (Expanded)
Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.
Cosmetic-Specific Mechanism
Category: other
Receptor targets: ERα (limited evidence)
LOEC: 100 µM
EU status: allowed
weak modulator
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE; GROUP
SVHC Candidate
No
Typical Use Concentrations
Reported concentration ranges per product category from SCCS/CIR/industry sources.
| Product Category | Typical Range | Max Reported | Source |
|---|---|---|---|
| Face Cream | 0.1–1 | 2 | CIR Safety Assessment |
| Sunscreen | 0.1–1 | 2 | CIR Safety Assessment |
| Body Lotion | 0.1–1 | 2 | CIR Safety Assessment |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Fragrance
Humectant
Pharmaceutical
Preservative
Softener and conditioner
Regulatory List Membership (4)
EU Regulated in Personal Care
EU Restricted for Children (Cosmetics)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
Editorial summary
Preliminary editorial summary for Vitamin E Oil — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
contact-dermatitis-risk
rare-sensitizer
gras-food
cir-reviewed-2018
widely-used
eu_children_restricted
epa_safer_alternative
ifra_fragrance
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Vitamin E Oil by CAS number or substance name.
Studies
2
Lowest NOAEL
500 mg/kg bw/day
Highest NOAEL
1600 mg/kg bw/day
ECHA
Known Synonyms
2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, 6-acetate
2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate
6-Chromanol, 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate
3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-yl acetate
3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-ylacetat
[2,5,7,8-Tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydrochromen-6-yl] acetate
2,5,7,8-Tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-chromen-6-yl acetate
acetate de 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyranne-6-yle
acetato de 3,4-dihidro-2,5,7,8-tetrametil-2-(4,8,12-trimetiltridecil)-2H-benzopirano-6-ilo
EINECS 231-710-0
Vitamin E acetate
EC No.: 231-710-0
231-710-0
Chemical Function
Preservative
Antioxidant
Fragrance
Pharmaceutical
Regulatory Lists
IFRA Transparency
inert_ingredient; non_food_use; Pesticides
SCIL (9/2019)
children; Europe; Personal care
children; Europe; Personal care - general moisturizing - hand/body lotion
children; Europe; Personal care - hair styling and care - shampoo
Europe; Personal care
Europe; Personal care
Europe; Personal care
Europe; Personal care
Europe; Personal care
Canada; Personal care; Substances in PCP - Canada (4/2014)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in food safety data.
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Vitamin E - DL-Alpha-Tocopheryl Acetate
Food Category
vitamins_minerals
Frequently Asked Questions
Is Vitamin E Oil allowed in the EU?
Vitamin E Oil EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Vitamin E Oil do in cosmetics?
Vitamin E Oil functions as: Antioxidant; stabilized vitamin E ester. It is classified as a Antioxidant in our database. CAS number: 7695-91-2.
What is the NOAEL for Vitamin E Oil?
The NOAEL (No Observed Adverse Effect Level) for Vitamin E Oil is =500 mg/kg bw/day based on a subchronic study via oral route in Rat. A total of 2 study endpoints are available. Source: ECHA.
Is Vitamin E Oil used outside cosmetics?
Vitamin E Oil also appears in industrial chemical safety and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Vitamin E Oil compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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