Also known as: Vitis vinifera leaf.ext, Vigne, extraits, Weintraube, Extrakt, uva, extracto, Grape, extract (+3 more)
INCI: VITIS VINIFERA (GRAPE) LEAF WATER
Vitis Vinifera Leaf Water (CAS 85594-37-2) is a cosmetic cosmetic ingredient functioning as Skin conditioning agent. Reported NOAEL =50 mg/kg bw/d in rat (CIR Safety Assessment); EU Regulation 1223/2009 status: permitted; 3 safety opinions reviewed (CIR Safety Assessment). Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 85594-37-2 →
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Margin of Safety, dermal absorption, and sensitization profile summaries for Vitis Vinifera Leaf Water.
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10 study endpoints found for Vitis Vinifera Leaf Water. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =50 mg/kg bw/d | oral | rat | inhalation toxicity | CIR Safety Assessment |
| NOAEL | =50 mg/kg bw/d | oral | rat | inhalation toxicity | CIR Safety Assessment |
| NOAEL | =50 mg/kg bw/d | oral | rat | inhalation toxicity | CIR Safety Assessment |
| NOAEL | =50 mg/kg bw/d | oral | rat | inhalation toxicity | CIR Safety Assessment |
| NOAEL | =300 mg/kg/d | oral | rat | oral toxicity | CIR Safety Assessment |
| NOAEL | =300 mg/kg/d | oral | rat | oral toxicity | CIR Safety Assessment |
| NOAEL | =300 mg/kg/d | oral | rat | oral toxicity | CIR Safety Assessment |
| NOAEL | =300 mg/kg/d | oral | rat | oral toxicity | CIR Safety Assessment |
| NOAEL | =2150 mg/kg bw/d | oral | rat | repeated dose toxicity | CIR Safety Assessment |
| NOAEL | =2150 mg/kg bw/d | oral | rat | repeated dose toxicity | CIR Safety Assessment |
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
Preliminary editorial summary for Vitis Vinifera Leaf Water — not a computed safety verdict. See the sourced toxicological data above.
Public NOAEL study rows linked to Vitis Vinifera Leaf Water by CAS number or substance name.
Units vary across source rows: mg/kg bw/d, mg/kg/d
Vitis Vinifera Leaf Water has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted. 10 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by CIR Safety Assessment.
Vitis Vinifera Leaf Water EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
Vitis Vinifera Leaf Water functions as: Skin conditioning agent. It is classified as a cosmetic ingredient in our database. CAS number: 85594-37-2.
The NOAEL (No Observed Adverse Effect Level) for Vitis Vinifera Leaf Water is =50 mg/kg bw/d based on a inhalation toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: CIR Safety Assessment.
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