Regulatory Status
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Safety Data
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Expert Verdict
⚠ GHS H317 skin sensitizer classification . Also classified H400: very toxic to aquatic life (environmental concern for wash-off products) . Estrogenic activity reported in literature — endocrine disruption potential should be considered. Patent literature suggests safe topical use at cosmetic concentrations , but independent safety dossier recommended. Phytoestrogenic properties require disclosure in regulatory submissions.
Regulatory Flags
Frequently Asked Questions
Is Xanthohumol safe in cosmetics?
⚠ GHS H317 skin sensitizer classification . Also classified H400: very toxic to aquatic life (environmental concern for wash-off products) . Estrogenic activity reported in literature — endocrine disruption potential should be considered. Patent literature suggests safe topical use at cosmetic concentrations , but independent safety dossier recommended. Phytoestrogenic properties require disclosure in regulatory submissions. The EU classifies Xanthohumol as "permitted". Safety rating: MODERATE.
Is Xanthohumol allowed in the EU?
Xanthohumol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Xanthohumol do in cosmetics?
Xanthohumol functions as: Skin conditioning; documented skin-brightening and anti-redness active (inhibits GM-CSF production). It is classified as a cosmetic ingredient in our database. CAS number: 6754-58-1.
What is the Margin of Safety for Xanthohumol?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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