Is Xanthohumol safe in cosmetics?
Xanthohumol has a safety rating of "MODERATE" in our database. EU status: permitted. US status: restricted.
Moderate
Cosmetic Ingredient
Xanthohumol
Also known as: 2-Propen-1-one, 1-[2,4-dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-, (2E)-, 2-Propen-1-one, 1-[2,4-dihydroxy-6-methoxy-3-(3-methyl-2-butenyl)phenyl]-3-(4-hydroxyphenyl)-, (2E)-, 2-Propen-1-one, 1-[2,4-dihydroxy-6-methoxy-3-(3-methyl-2-butenyl)phenyl]-3-(4-hydroxyphenyl)-, (E)-, (2E)-1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one, Xantho Flav-Pure (+4 more)
INCI: XANTHOHUMOL
Xanthohumol (CAS 6754-58-1) is a cosmetic cosmetic ingredient functioning as Skin conditioning; documented skin-brightening and anti-redness active. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 6754-58-1 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning; documented skin-brightening and anti-redness active (inhibits GM-CSF production)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
(E)-1-[2,4-dihydroxy-6-methoxy-3-(3-methylbut-2-enyl)phenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one
InChIKey
ORXQGKIUCDPEAJ-YRNVUSSQSA-N
Regulatory Status
EU EU Status
permitted
US US Status
restricted
US Notes
Not specifically restricted; CIR panel reviewed hops-derived ingredients as safe in present practices of use
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Xanthohumol.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Xanthohumol.
Regulatory Flags
potential-allergen
endocrine_disruptor
Known Synonyms
2-Propen-1-one, 1-[2,4-dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-, (2E)-
2-Propen-1-one, 1-[2,4-dihydroxy-6-methoxy-3-(3-methyl-2-butenyl)phenyl]-3-(4-hydroxyphenyl)-, (2E)-
2-Propen-1-one, 1-[2,4-dihydroxy-6-methoxy-3-(3-methyl-2-butenyl)phenyl]-3-(4-hydroxyphenyl)-, (E)-
(2E)-1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one
Xantho Flav-Pure
Xantho-Flav
EC No.: 614-078-4
614-078-4
Xanthopure
Chemical Function
Softener and conditioner
Regulatory Lists
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
XANTHOHUMOL
ChEMBL ID
CHEMBL253896
Max Phase
2
Frequently Asked Questions
Is Xanthohumol allowed in the EU?
Xanthohumol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Xanthohumol do in cosmetics?
Xanthohumol functions as: Skin conditioning; documented skin-brightening and anti-redness active (inhibits GM-CSF production). It is classified as a cosmetic ingredient in our database. CAS number: 6754-58-1.
Is Xanthohumol used outside cosmetics?
Xanthohumol also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Xanthohumol compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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Solvent
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