Xylene Diisocyanate

INCI: XYLENE DIISOCYANATE

CAS Number
3634-83-1 (m-XDI); 25854-16-4 (mixture)
Function
Crosslinking agent / polymer precursor (not a direct cosmetic functional ingredient)
Safety Rating
POOR

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status prohibited
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Not permitted in cosmetic formulations; classified as hazardous industrial chemical

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
high
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

BANNED/RESTRICTED; severe respiratory sensitizer (occupational asthma); contact dermatitis; REACH restriction applies from August 2023; no legitimate use in finished cosmetics

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Concern Level: High

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Xylene Diisocyanate safe in cosmetics?

BANNED/RESTRICTED; severe respiratory sensitizer (occupational asthma); contact dermatitis; REACH restriction applies from August 2023; no legitimate use in finished cosmetics The EU classifies Xylene Diisocyanate as "prohibited". Safety rating: POOR.

Is Xylene Diisocyanate allowed in the EU?

Xylene Diisocyanate EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Xylene Diisocyanate do in cosmetics?

Xylene Diisocyanate functions as: Crosslinking agent / polymer precursor (not a direct cosmetic functional ingredient). It is classified as a cosmetic ingredient in our database. CAS number: 3634-83-1 (m-XDI); 25854-16-4 (mixture).

What is the Margin of Safety for Xylene Diisocyanate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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