Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Xanthan Gum. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 1000 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
| NOAEL | 500 mg/kg bw/day | oral | rat | Multigeneration Reproductive | COSMOS_DB |
| NOAEL | 500 mg/kg bw/day | oral | dog | Subchronic | COSMOS_DB |
| NOAEL | 2000 mg/kg bw/day | oral | dog | Subchronic | COSMOS_DB |
| NOAEL | 500 mg/kg bw/day | oral | dog | Chronic | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | dog | Chronic | COSMOS_DB |
| NOAEL | 2000 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 3250 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 7500 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
Dermal Penetration Profile
Skin absorption and penetration characteristics of Xanthan Gum, relevant to systemic exposure and MoS calculations.
Source: CIR
Expert Verdict
The benchmark natural thickener with exceptional pH stability (2-12), excellent salt tolerance, and outstanding particle suspension. Pseudoplastic/shear-thinning properties prevent sedimentation at rest while enabling easy spreading under shear. Fully biodegradable and COSMOS/ECOCERT compliant. Best used at 0.1-1.0% in synergistic blends with locust bean gum or sclerotium gum.
Regulatory Flags
Frequently Asked Questions
Is Xanthan Gum safe in cosmetics?
The benchmark natural thickener with exceptional pH stability (2-12), excellent salt tolerance, and outstanding particle suspension. Pseudoplastic/shear-thinning properties prevent sedimentation at rest while enabling easy spreading under shear. Fully biodegradable and COSMOS/ECOCERT compliant. Best used at 0.1-1.0% in synergistic blends with locust bean gum or sclerotium gum. The EU classifies Xanthan Gum as "permitted". Safety rating: EXCELLENT. 10 toxicological study endpoint(s) are available in our database.
Is Xanthan Gum allowed in the EU?
Xanthan Gum EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Xanthan Gum do in cosmetics?
Xanthan Gum functions as: Rheology modifier, thickener, stabilizer, suspending agent. It is classified as a cosmetic ingredient in our database. CAS number: 11138-66-2.
What is the Margin of Safety for Xanthan Gum?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Xanthan Gum?
The NOAEL (No Observed Adverse Effect Level) for Xanthan Gum is 1000 mg/kg bw/day based on a Carcinogenicity study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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