Good Cosmetic Ingredient NOAEL Data GHS Classified

1,6-HEXAMETHYLENE DIISOCYANATE

CAS Number

822-06-0

Function

Not Reported

Safety Rating

GOOD

Regulatory Status

🇪🇺 EU Status Permitted

🇺🇸 US Status Not specifically regulated

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Toxicological Studies

3 study endpoints found for 1,6-HEXAMETHYLENE DIISOCYANATE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint	Value	Route	Species	Study Type	Source
NOAEL	300 mg/kg bw/day	oral	rat	oral	REACH
LOAEL	0.01 2284	1995	rat	inhalation	REACH
NOAEL	0.2 ppm	1991	rat	inhalation	REACH

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Signal Word

DANGER

Pictograms

skull;toxic; cancer;health haz

Hazard Statements

Fatal if inhaled Toxic in contact with skin Causes serious eye irritation Causes skin irritation May cause respiratory irritation May cause allergy or asthma symptoms or breathing difficulties if inhaled May cause an allergic skin reaction

Short-term Exposure Effects

The substance is severely irritating to the eyes. The substance is irritating to the skin and respiratory tract. Inhalation may cause asthmatic reactions.

Long-term Exposure Effects

Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation may cause asthma. See Notes.

Routes of Exposure

The substance can be absorbed into the body by inhalation of its aerosol or vapour and through the skin.

Expert Verdict

1,6-HEXAMETHYLENE DIISOCYANATE is listed in the EU CosIng database with functions: Not Reported It is permitted in the EU without specific restrictions.

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Concern Level: Low

Regulatory Flags

cosing-sourced eu-permitted needs-enrichment

Frequently Asked Questions

Is 1,6-HEXAMETHYLENE DIISOCYANATE safe in cosmetics?

1,6-HEXAMETHYLENE DIISOCYANATE is listed in the EU CosIng database with functions: Not Reported It is permitted in the EU without specific restrictions. The EU classifies 1,6-HEXAMETHYLENE DIISOCYANATE as "Permitted". Safety rating: GOOD. 3 toxicological study endpoint(s) are available in our database.

Is 1,6-HEXAMETHYLENE DIISOCYANATE allowed in the EU?

1,6-HEXAMETHYLENE DIISOCYANATE EU regulatory status: Permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does 1,6-HEXAMETHYLENE DIISOCYANATE do in cosmetics?

1,6-HEXAMETHYLENE DIISOCYANATE functions as: Not Reported. It is classified as a cosmetic ingredient in our database. CAS number: 822-06-0.

What is the NOAEL for 1,6-HEXAMETHYLENE DIISOCYANATE?

The NOAEL (No Observed Adverse Effect Level) for 1,6-HEXAMETHYLENE DIISOCYANATE is 300 mg/kg bw/day based on a oral study via oral route in rat. A total of 3 study endpoints are available. Source: REACH.

Is 1,6-HEXAMETHYLENE DIISOCYANATE classified as hazardous under GHS?

1,6-HEXAMETHYLENE DIISOCYANATE carries a GHS signal word of "DANGER". Hazard statements: Fatal if inhaled Toxic in contact with skin Causes serious eye irritation Causes skin irritation May cause respiratory irritation May cause allergy or asthma symptoms or breathing difficulties if inhaled May cause an allergic skin reaction. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.

Compliance Tools

Check 1,6-HEXAMETHYLENE DIISOCYANATE compliance across multiple jurisdictions:

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Substance Compliance

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