Moderate Cosmetic Ingredient NOAEL Data GHS Classified

2-BROMO-2-NITROPROPANE-1,3-DIOL

CAS Number

52-51-7

Function

Preservative

Safety Rating

MODERATE

Regulatory Status

🇪🇺 EU Status Restricted

EU Max Conc. V/21

🇺🇸 US Status restricted

US Notes CIR: SQ - JEPT 4(4):47-61, 1980; JACT 3(3):139-155, 1984; IJT 25(Suppl. 2):1-89, 2006

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Toxicological Studies

9 study endpoints found for 2-BROMO-2-NITROPROPANE-1,3-DIOL. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint	Value	Route	Species	Study Type	Source
NOAEL	0.2 other	dermal	code:3484	dermal	REACH
NOAEL	7 mg/kg bw/day	oral	rat	oral	REACH
NOAEL	0.2 other	dermal	code:3543	dermal	REACH
NOAEL	20 mg/kg bw/day	oral	rat	oral	REACH
NOAEL	250 ppm	oral	rat	oral	REACH
LOAEL	0.15 other	oral	rat	oral	REACH
NOAEL	8 mg/kg bw/day	oral	dog	oral	REACH
NOEL	0.05 other	oral	dog	oral	REACH
NOEL	0.05 other	oral	dog	oral	REACH

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Signal Word

DANGER

Pictograms

flam;flame; corr; excl mark;warn; enviro;aqua

Hazard Statements

Flammable solid Harmful if swallowed or in contact with skin Causes skin irritation Causes serious eye damage May cause respiratory irritation Very toxic to aquatic life with long lasting effects

Short-term Exposure Effects

The substance is corrosive to the eyes. The substance is irritating to the skin and respiratory tract.

Long-term Exposure Effects

Repeated or prolonged contact may cause skin sensitization.

Routes of Exposure

The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion.

Expert Verdict

2-BROMO-2-NITROPROPANE-1,3-DIOL is listed in the EU CosIng database with functions: Preservative It is restricted under EU Cosmetics Regulation. Restriction: V/21.

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Concern Level: Medium

Regulatory Flags

cosing-sourced eu-restricted preservative needs-enrichment eu_children_restricted eu_cosing_listed

Frequently Asked Questions

Is 2-BROMO-2-NITROPROPANE-1,3-DIOL safe in cosmetics?

2-BROMO-2-NITROPROPANE-1,3-DIOL is listed in the EU CosIng database with functions: Preservative It is restricted under EU Cosmetics Regulation. Restriction: V/21. The EU classifies 2-BROMO-2-NITROPROPANE-1,3-DIOL as "Restricted". Safety rating: MODERATE. 9 toxicological study endpoint(s) are available in our database.

Is 2-BROMO-2-NITROPROPANE-1,3-DIOL allowed in the EU?

2-BROMO-2-NITROPROPANE-1,3-DIOL EU regulatory status: Restricted. Maximum allowed concentration: V/21. This is based on EU Regulation 1223/2009 and its amendments.

What does 2-BROMO-2-NITROPROPANE-1,3-DIOL do in cosmetics?

2-BROMO-2-NITROPROPANE-1,3-DIOL functions as: Preservative. It is classified as a cosmetic ingredient in our database. CAS number: 52-51-7.

What is the NOAEL for 2-BROMO-2-NITROPROPANE-1,3-DIOL?

The NOAEL (No Observed Adverse Effect Level) for 2-BROMO-2-NITROPROPANE-1,3-DIOL is 0.2 other based on a dermal study via dermal route in code:3484. A total of 9 study endpoints are available. Source: REACH.

Is 2-BROMO-2-NITROPROPANE-1,3-DIOL classified as hazardous under GHS?

2-BROMO-2-NITROPROPANE-1,3-DIOL carries a GHS signal word of "DANGER". Hazard statements: Flammable solid Harmful if swallowed or in contact with skin Causes skin irritation Causes serious eye damage May cause respiratory irritation Very toxic to aquatic life with long lasting effects. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.

Compliance Tools

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