Moderate Cosmetic Ingredient NOAEL Data GHS Classified

2-Bromo-2-Nitropropane-1,3-Diol (Bronopol)

INCI: 2-BROMO-2-NITROPROPANE-1,3-DIOL

CAS Number

52-51-7

Function

Preservative (formaldehyde releaser)

Safety Rating

MODERATE

Regulatory Status

🇪🇺 EU Status restricted

EU Max Conc. 0.1%

🇺🇸 US Status permitted

US Notes CIR Panel concluded safe up to 0.1%, provided it is not used with amines/amides that could form nitrosamines

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)

adequate

Dermal Absorption

low

Sensitization

moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

9 study endpoints found for 2-Bromo-2-Nitropropane-1,3-Diol (Bronopol). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint	Value	Route	Species	Study Type	Source
NOAEL	0.2 other	dermal	code:3484	dermal	REACH
NOAEL	7 mg/kg bw/day	oral	rat	oral	REACH
NOAEL	0.2 other	dermal	code:3543	dermal	REACH
NOAEL	20 mg/kg bw/day	oral	rat	oral	REACH
NOAEL	250 ppm	oral	rat	oral	REACH
LOAEL	0.15 other	oral	rat	oral	REACH
NOAEL	8 mg/kg bw/day	oral	dog	oral	REACH
NOEL	0.05 other	oral	dog	oral	REACH
NOEL	0.05 other	oral	dog	oral	REACH

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Signal Word

DANGER

Pictograms

flam;flame; corr; excl mark;warn; enviro;aqua

Hazard Statements

Flammable solid Harmful if swallowed or in contact with skin Causes skin irritation Causes serious eye damage May cause respiratory irritation Very toxic to aquatic life with long lasting effects

Short-term Exposure Effects

The substance is corrosive to the eyes. The substance is irritating to the skin and respiratory tract.

Long-term Exposure Effects

Repeated or prolonged contact may cause skin sensitization.

Routes of Exposure

The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion.

Expert Verdict

⚠️

Concern Level: Moderate

Regulatory Flags

preservative eu_children_restricted eu_cosing_listed

Frequently Asked Questions

Is 2-Bromo-2-Nitropropane-1,3-Diol (Bronopol) safe in cosmetics?

Formaldehyde releaser that must not be combined with amines/amides due to nitrosamine formation risk; banned in Japan and increasingly restricted in clean beauty and COSMOS/ECOCERT frameworks; not suitable for aerosol products The EU classifies 2-Bromo-2-Nitropropane-1,3-Diol (Bronopol) as "restricted". Safety rating: MODERATE. 9 toxicological study endpoint(s) are available in our database.

Is 2-Bromo-2-Nitropropane-1,3-Diol (Bronopol) allowed in the EU?

2-Bromo-2-Nitropropane-1,3-Diol (Bronopol) EU regulatory status: restricted. Maximum allowed concentration: 0.1%. This is based on EU Regulation 1223/2009 and its amendments.

What does 2-Bromo-2-Nitropropane-1,3-Diol (Bronopol) do in cosmetics?

2-Bromo-2-Nitropropane-1,3-Diol (Bronopol) functions as: Preservative (formaldehyde releaser). It is classified as a cosmetic ingredient in our database. CAS number: 52-51-7.

What is the Margin of Safety for 2-Bromo-2-Nitropropane-1,3-Diol (Bronopol)?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for 2-Bromo-2-Nitropropane-1,3-Diol (Bronopol)?

The NOAEL (No Observed Adverse Effect Level) for 2-Bromo-2-Nitropropane-1,3-Diol (Bronopol) is 0.2 other based on a dermal study via dermal route in code:3484. A total of 9 study endpoints are available. Source: REACH.

Is 2-Bromo-2-Nitropropane-1,3-Diol (Bronopol) classified as hazardous under GHS?

2-Bromo-2-Nitropropane-1,3-Diol (Bronopol) carries a GHS signal word of "DANGER". Hazard statements: Flammable solid Harmful if swallowed or in contact with skin Causes skin irritation Causes serious eye damage May cause respiratory irritation Very toxic to aquatic life with long lasting effects. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.

Compliance Tools

Check 2-Bromo-2-Nitropropane-1,3-Diol (Bronopol) compliance across multiple jurisdictions:

🔬

Ingredient Decoder

Paste a full ingredient list for instant analysis

🌸

82 Allergen Checker

Check for EU declarable fragrance allergens

🧪

Substance Compliance

Check compliance across 55 jurisdictions

🧮

MoS Calculator

Calculate Margin of Safety using SCCS methodology

⚗️

Heavy Metal Limits

Compare limits across jurisdictions

Related Ingredients

Phenethyl Phenoxy Methyldihydropyrroloquinoline HCl

Moderate

Fluorosalan

Poor

Phenoxyethyl PCA

Good

Ficus benghalensis Bark/Bud Extract

Moderate

Undecylenoyl PEG-5 Paraben

Moderate

Browse all 30,000+ ingredients →

📱

Is 2-Bromo-2-Nitropropane-1,3-Diol (Bronopol) in Your Products?

Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free →

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for 2-Bromo-2-Nitropropane-1,3-Diol (Bronopol) in your formulation.

Ingredient Decoder MoS Calculator