Poor Cosmetic Ingredient

2-Chloro-5-Nitro-N-Hydroxyethyl P-Phenylenediamine

INCI: 2-CHLORO-5-NITRO-N-HYDROXYETHYL P-PHENYLENEDIAMINE

CAS Number
50610-28-1
Function
Hair dyeing (semi-permanent/direct dye)
Safety Rating
POOR

Regulatory Status

🇪🇺 EU Status prohibited
🇺🇸 US Status permitted
US Notes No specific FDA prohibition; coal-tar hair dyes carry the statutory exemption with caution labeling under FD&C Act §601(a)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Banned in EU (Annex II); amine/nitro compound with potential mutagenicity concerns and cross-sensitization risk with other PPD derivatives.

⚠️
Concern Level: High

Regulatory Flags

potential-allergen eu_banned_cosmetics eu_cosing_listed

Frequently Asked Questions

Is 2-Chloro-5-Nitro-N-Hydroxyethyl P-Phenylenediamine safe in cosmetics?

Banned in EU (Annex II); amine/nitro compound with potential mutagenicity concerns and cross-sensitization risk with other PPD derivatives. The EU classifies 2-Chloro-5-Nitro-N-Hydroxyethyl P-Phenylenediamine as "prohibited". Safety rating: POOR.

Is 2-Chloro-5-Nitro-N-Hydroxyethyl P-Phenylenediamine allowed in the EU?

2-Chloro-5-Nitro-N-Hydroxyethyl P-Phenylenediamine EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does 2-Chloro-5-Nitro-N-Hydroxyethyl P-Phenylenediamine do in cosmetics?

2-Chloro-5-Nitro-N-Hydroxyethyl P-Phenylenediamine functions as: Hair dyeing (semi-permanent/direct dye). It is classified as a cosmetic ingredient in our database. CAS number: 50610-28-1.

What is the Margin of Safety for 2-Chloro-5-Nitro-N-Hydroxyethyl P-Phenylenediamine?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check 2-Chloro-5-Nitro-N-Hydroxyethyl P-Phenylenediamine compliance across multiple jurisdictions:

🔬
Ingredient Decoder
Paste a full ingredient list for instant analysis
 🌸
82 Allergen Checker
Check for EU declarable fragrance allergens
 🧪
Substance Compliance
Check compliance across 55 jurisdictions
 🧮
MoS Calculator
Calculate Margin of Safety using SCCS methodology
 ⚗️
Heavy Metal Limits
Compare limits across jurisdictions

Related Ingredients

Acid Orange 3
Poor
Arrabidaea Chica Leaf/Stem Extract
Moderate
Diisobutyl Dicyanoperylenedicarboxylate
Moderate
Pigment Red 57:1
Excellent
Hibiscus Sabdariffa Flower
Good
Browse all 30,000+ ingredients →
📱

Is 2-Chloro-5-Nitro-N-Hydroxyethyl P-Phenylenediamine in Your Products?

Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free →

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for 2-Chloro-5-Nitro-N-Hydroxyethyl P-Phenylenediamine in your formulation.

Ingredient Decoder MoS Calculator