Is 2-Hexyl-1,3-Dioxolane safe in cosmetics?
2-Hexyl-1,3-Dioxolane has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
MODERATE
Cosmetic Ingredient
2-Hexyl-1,3-Dioxolane
INCI: 2-HEXYL-1,3-DIOXOLANE
2-Hexyl-1,3-Dioxolane (CAS 1599-49-1) is a cosmetic cosmetic ingredient functioning as Fragrance / Perfuming. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and food safety data.
Function
Fragrance / Perfuming
Editorial assessment
MODERATE
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
4-methyl-2-pentyl-1,3-dioxolane
InChIKey
GWMSIWCZZKMUQM-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not specifically restricted by FDA
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 2-Hexyl-1,3-Dioxolane.
Calculate MoS for your specific formulation with the MoS Calculator.
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
928
Source: WHO/JECFA
JECFA Evaluation
4-METHYL-2-PENTYL-1,3-DIOXOLANE | 2001 | No safety concern at current levels of intake when used as a flavouring agent | TRS 909-JECFA 57/98 | FAS 48-JECFA 57/333
Source: WHO/JECFA
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Editorial summary
Preliminary editorial summary for 2-Hexyl-1,3-Dioxolane — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
Chemical Function
Flavouring and nutrient
Regulatory Lists
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in food safety data.
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
4-METHYL-2-PENTYL-1,3-DIOXOLANE
ADI
No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
Food Category
flavoring
Frequently Asked Questions
Is 2-Hexyl-1,3-Dioxolane allowed in the EU?
2-Hexyl-1,3-Dioxolane EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 2-Hexyl-1,3-Dioxolane do in cosmetics?
2-Hexyl-1,3-Dioxolane functions as: Fragrance / Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 1599-49-1.
Is 2-Hexyl-1,3-Dioxolane used outside cosmetics?
2-Hexyl-1,3-Dioxolane also appears in industrial chemical safety and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check 2-Hexyl-1,3-Dioxolane compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
2,6-Dimethyl-7-octen-2-ol (Dihydromyrcenol)
EXCELLENT
Same category
Fragrance (perfuming), masking
2-Ethoxy-2,6,6-Trimethyl-9-Methylenebicyclo[3.3.1]Nonane (Boisiris™)
EXCELLENT
Same category
Fragrance (rich woody, orris/iris roo...
3,6-Dimethyl-3-Octyl Acetate
EXCELLENT
Same category
Fragrance / Perfuming agent with flor...
3-Methyl-5-(2,2,3-Trimethyl-3-Cyclopentenyl)Pent-4-En-2-Ol (Sandalore)
EXCELLENT
Same category
Perfuming / Fragrance (sandalwood note)
4-Tert-Butylcyclohexyl Acetate
EXCELLENT
Same category
Fragrance
Acetoin
EXCELLENT
Same category
Skin conditioning, fragrance
(20S)-Protopanaxadiol
MODERATE
Similar safety
(Cnidium Officinale/Coptis Chinensis/Glycyrrhiza Uralensis) Root Extract
MODERATE
Similar safety
Skin conditioning
(Cryptomeria Japonica/Chamaecyparis Obtusa) Stem Ferment Extract
MODERATE
Similar safety
Antimicrobial, antioxidant, humectant
(Eclipta Prostrata/Houttuynia Cordata) Leaf Extract
MODERATE
Similar safety
Skin conditioning
(Lepidium Meyenii/Sarcodon Aspratus) Root Water
MODERATE
Similar safety
Skin conditioning
(Licorice/Reynoutria Japonica) Root/Stem Extract
MODERATE
Similar safety
Skin conditioning, antioxidant
2-Hexyl-1,3-Dioxolane-4-Methanol
MODERATE
Chemical family
Fragrance / Perfuming
2-Heptanol
GOOD
Browse nearby
Flavouring and nutrient; Fragrance
2-Heptylcyclopentanone
GOOD
Browse nearby
Fragrance ingredient (cyclopentanone ...
Is 2-Hexyl-1,3-Dioxolane in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for 2-Hexyl-1,3-Dioxolane in your formulation.