Is 2-Hexylidenecyclopentanone ⚠️ safe in cosmetics?
2-Hexylidenecyclopentanone ⚠️ has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
2-Hexylidenecyclopentanone ⚠️
INCI: 2-HEXYLIDENECYCLOPENTANONE
2-Hexylidenecyclopentanone ⚠️ (CAS 17373-89-6) is a cosmetic cosmetic ingredient functioning as Fragrance / Perfuming. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 17373-89-6 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance / Perfuming
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
(2E)-2-hexylidenecyclopentan-1-one
InChIKey
WZPGQHVPSKTELT-JXMROGBWSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not specifically restricted by FDA; IFRA limits observed
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 2-Hexylidenecyclopentanone ⚠️.
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
DPRA Cys %
96.72%
DPRA Lys %
6.72%
KeratinoSens IC50
96.487 µM
hCLAT CV75
19.775 µg/mL
LLNA EC3
2.4%
NESIL
111 µg/cm²
LLNA: Moderate (1B)
GHS: 1B
Human: positive
Source: LLNA: personal communication by RIFM (RIFM DB #55548); DPRA: Unilever commissioned, Charles River | Unilever commissioned, IIVS; KS: Natsch et al. 2015 [DOI:10.1093/toxsci/kfu229]; hCLAT: Unilever commissioned, IIVS; HPPT: [402] RIFM (1979): RIFM report number 1697, September 14, unpublished.
HRIPT Human Patch Test Studies
5 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HRIPT | - | 0 | 300 | 300 | strong |
| HMT | - | 0 | 3375 | - | - |
| HMT | - | 0 | 3375 | - | - |
| HRIPT | - | 0 | 300 | - | - |
| HRIPT | - | 0 | 111 | - | - |
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
Product type: (a) Oral products (b) Other products. Max: (b) 0.06%.
BRIN Brazil/India Cosmetics
India: Restricted · max (b) 0.06%
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
1106
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
2-HEXYLIDENE CYCLOPENTANONE | 2002 | No safety concern at current levels of intake when used as a flavouring agent | TRS 913-JECFA 59/95 | FAS 50-JECFA 59/331
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (4)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for 2-Hexylidenecyclopentanone ⚠️.
Regulatory Flags
potential-allergen
fragrance-component
ifra_fragrance
fda_food_additive
eu_cosing_listed
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Europe
Europe; Personal care; restricted
Australian Status
AICIS status: listed
Frequently Asked Questions
Is 2-Hexylidenecyclopentanone ⚠️ allowed in the EU?
2-Hexylidenecyclopentanone ⚠️ EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 2-Hexylidenecyclopentanone ⚠️ do in cosmetics?
2-Hexylidenecyclopentanone ⚠️ functions as: Fragrance / Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 17373-89-6.
Is 2-Hexylidenecyclopentanone ⚠️ used outside cosmetics?
2-Hexylidenecyclopentanone ⚠️ also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check 2-Hexylidenecyclopentanone ⚠️ compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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