Poor Cosmetic Ingredient GHS Classified

2-Hydroxypropyl Acrylate

INCI: HYDROXYPROPYL ACRYLATE

CAS Number
999-61-1
Function
Film forming for nail products and adhesives
Safety Rating
POOR

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted in cosmetics; acrylates copolymers reviewed by CIR

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Signal Word
DANGER
Pictograms
corr; skull;toxic; cancer;health haz
Hazard Statements
Combustible liquid Toxic if swallowed Fatal in contact with skin Causes severe skin burns and eye damage May cause an allergic skin reaction May cause damage to respiratory tract if inhaled May be harmful if swallowed and enters airways Toxic to aquatic life
Short-term Exposure Effects
The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation may cause lung oedema, but only after initial corrosive effects on eyes and/or airways have become manifest. If swallowed the substance may cause vomiting and could result in aspiration pneumonitis. See Notes.
Long-term Exposure Effects
Repeated or prolonged contact with skin may cause dermatitis. Repeated or prolonged contact may cause skin sensitization. See Notes.
Routes of Exposure
The substance can be absorbed into the body through the skin and by ingestion. Serious local effects by all routes of exposure.

Expert Verdict

Classified as H301 (toxic if swallowed), H311 (toxic dermal), H314 (severe burns/eye damage), and H317 (skin sensitizer); one of the more hazardous acrylate monomers.

⚠️
Concern Level: High

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is 2-Hydroxypropyl Acrylate safe in cosmetics?

Classified as H301 (toxic if swallowed), H311 (toxic dermal), H314 (severe burns/eye damage), and H317 (skin sensitizer); one of the more hazardous acrylate monomers. The EU classifies 2-Hydroxypropyl Acrylate as "permitted". Safety rating: POOR.

Is 2-Hydroxypropyl Acrylate allowed in the EU?

2-Hydroxypropyl Acrylate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does 2-Hydroxypropyl Acrylate do in cosmetics?

2-Hydroxypropyl Acrylate functions as: Film forming for nail products and adhesives. It is classified as a cosmetic ingredient in our database. CAS number: 999-61-1.

What is the Margin of Safety for 2-Hydroxypropyl Acrylate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Is 2-Hydroxypropyl Acrylate classified as hazardous under GHS?

2-Hydroxypropyl Acrylate carries a GHS signal word of "DANGER". Hazard statements: Combustible liquid Toxic if swallowed Fatal in contact with skin Causes severe skin burns and eye damage May cause an allergic skin reaction May cause damage to respiratory tract if inhaled May be harmful if swallowed and enters airways Toxic to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.

Compliance Tools

Check 2-Hydroxypropyl Acrylate compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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