Moderate Cosmetic Ingredient GHS Classified

4-Methylpent-3-En-2-One (Mesityl Oxide)

CAS Number
141-79-7
Function
Flavouring and nutrient; Fragrance; Solvent
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Not specifically restricted by FDA for cosmetic use

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Signal Word
DANGER
Pictograms
flam;flame; skull;toxic; cancer;health haz
Hazard Statements
Flammable liquid and vapour Harmful if swallowed Toxic if inhaled Causes skin and eye irritation May cause respiratory irritation May cause damage to organs through prolonged or repeated exposure May be harmful if swallowed and enters airways Harmful to aquatic life
Short-term Exposure Effects
The substance is irritating to the eyes, skin and respiratory tract. Exposure far above the OEL could cause unconsciousness. If swallowed the substance may cause vomiting and could result in aspiration pneumonitis.
Long-term Exposure Effects
The substance defats the skin, which may cause dryness or cracking. The substance may have effects on the liver, kidneys and lungs.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its vapour and by ingestion.

Expert Verdict

GHS classified as irritant. Vegetable-type odor used at very low concentrations in fragrance compositions.

⚠️
Concern Level: Moderate

Regulatory Flags

fragrance-component ifra_fragrance fda_food_additive

Frequently Asked Questions

Is 4-Methylpent-3-En-2-One (Mesityl Oxide) safe in cosmetics?

GHS classified as irritant. Vegetable-type odor used at very low concentrations in fragrance compositions. The EU classifies 4-Methylpent-3-En-2-One (Mesityl Oxide) as "permitted". Safety rating: MODERATE.

Is 4-Methylpent-3-En-2-One (Mesityl Oxide) allowed in the EU?

4-Methylpent-3-En-2-One (Mesityl Oxide) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does 4-Methylpent-3-En-2-One (Mesityl Oxide) do in cosmetics?

4-Methylpent-3-En-2-One (Mesityl Oxide) functions as: Flavouring and nutrient; Fragrance; Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 141-79-7.

What is the Margin of Safety for 4-Methylpent-3-En-2-One (Mesityl Oxide)?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Is 4-Methylpent-3-En-2-One (Mesityl Oxide) classified as hazardous under GHS?

4-Methylpent-3-En-2-One (Mesityl Oxide) carries a GHS signal word of "DANGER". Hazard statements: Flammable liquid and vapour Harmful if swallowed Toxic if inhaled Causes skin and eye irritation May cause respiratory irritation May cause damage to organs through prolonged or repeated exposure May be harmful if swallowed and enters airways Harmful to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.

Compliance Tools

Check 4-Methylpent-3-En-2-One (Mesityl Oxide) compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
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