Is 4-Methylquinoline (Lepidine) safe in cosmetics?
4-Methylquinoline (Lepidine) has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: restricted.
Moderate
Cosmetic Ingredient
4-Methylquinoline (Lepidine)
Also known as: 5-20-07-00389, BRN 0110926, EINECS 207-734-2, 4-Lepidine, gamma-Methylquinoline (+1 more)
INCI: 4-METHYLQUINOLINE
4-Methylquinoline (Lepidine) (CAS 491-35-0) is a cosmetic cosmetic ingredient functioning as Fragrance. EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 491-35-0 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance
Safety Rating
MODERATE
Regulatory Status
EU EU Status
prohibited
US US Status
restricted
US Notes
Not specifically restricted by FDA for cosmetic use
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 4-Methylquinoline (Lepidine).
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for 4-Methylquinoline (Lepidine).
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
Known Synonyms
5-20-07-00389
BRN 0110926
EINECS 207-734-2
4-Lepidine
gamma-Methylquinoline
p-Methylquinoline
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL9734
Frequently Asked Questions
Is 4-Methylquinoline (Lepidine) allowed in the EU?
4-Methylquinoline (Lepidine) EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does 4-Methylquinoline (Lepidine) do in cosmetics?
4-Methylquinoline (Lepidine) functions as: Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 491-35-0.
Is 4-Methylquinoline (Lepidine) used outside cosmetics?
4-Methylquinoline (Lepidine) also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check 4-Methylquinoline (Lepidine) compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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