Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Acetophenone. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 102 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 300 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 0.05 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 500 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 0.5 mg/kg bw/day | oral | rabbit | Chronic | COSMOS_DB |
| NOAEL | 8450 ppm | oral | rat | Subchronic | COSMOS_DB |
| dose_tested | 102 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| dose_tested | 500 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 250 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 225 mg/kg bw/day | oral | rat | oral | REACH |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
Mild skin/eye irritant at concentrated levels. Commonly used in cosmetics as a fragrance, assessed for consumer safety and not classified as CMR. IFRA-compliant with no specific restrictions.
Regulatory Flags
Frequently Asked Questions
Is Acetophenone safe in cosmetics?
Mild skin/eye irritant at concentrated levels. Commonly used in cosmetics as a fragrance, assessed for consumer safety and not classified as CMR. IFRA-compliant with no specific restrictions. The EU classifies Acetophenone as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.
Is Acetophenone allowed in the EU?
Acetophenone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Acetophenone do in cosmetics?
Acetophenone functions as: Fragrance, masking agent. It is classified as a cosmetic ingredient in our database. CAS number: 98-86-2.
What is the Margin of Safety for Acetophenone?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Acetophenone?
The NOAEL (No Observed Adverse Effect Level) for Acetophenone is 102 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Is Acetophenone classified as hazardous under GHS?
Acetophenone carries a GHS signal word of "WARNING". Hazard statements: Harmful if swallowed May be harmful in contact with skin Causes eye irritation. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Compliance Tools
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Related Ingredients
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