Also known as: 5-17-07-00110, beta-Arbutin, BRN 0089673, EINECS 207-850-3, Hydroquinone beta-D-glucopyranoside (+10 more)
INCI: ARBUTIN
Arbutin (Alpha-Arbutin and Beta-Arbutin) (CAS 497-76-7) is a cosmetic cosmetic ingredient functioning as Skin Brightening. NOAEL 20 mg/kg bw/day (PDF-verified against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted, max 2% face / 0.5% body. Industrial safety data is also available in the chemical safety database.
US NotesNo specific US limit. FDA HQ connection via 21 CFR 310.545.
For full compliance data across multiple jurisdictions, use the
Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Arbutin (Alpha-Arbutin and Beta-Arbutin).
Calculate MoS for your specific formulation with the
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Toxicological Studies
10 study endpoints found for Arbutin (Alpha-Arbutin and Beta-Arbutin). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
Endpoint
Value
Route
Species
Study Type
Source
NOAEL
=0.0005 mg/kg bw/d
dermal
-
dermal absorption
SCCS Opinion
NOAEL
=0.0005 mg/kg bw/d
dermal
-
dermal absorption
SCCS Opinion
NOAEL
=0.0005 mg/kg bw/d
dermal
-
dermal absorption
SCCS Opinion
NOAEL
=0.0005 mg/kg bw/d
dermal
-
dermal absorption
SCCS Opinion
NOAEL
=0.00076 mg/kg bw/d
dermal
-
dermal absorption
SCCS Opinion
NOAEL
=0.00076 mg/kg bw/d
dermal
-
dermal absorption
SCCS Opinion
NOAEL
=0.00076 mg/kg bw/d
dermal
-
dermal absorption
SCCS Opinion
NOAEL
=0.00076 mg/kg bw/d
dermal
-
dermal absorption
SCCS Opinion
NOAEL
=15 mg/kg/day
oral
rat
reproductive toxicity
SCCS Opinion
NOAEL
=15 mg/kg/day
oral
rat
reproductive toxicity
SCCS Opinion
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Arbutin (Alpha-Arbutin and Beta-Arbutin) across SCCS product categories, with measured dermal absorption where available.
Endocrine Disruptor Evidence (Expanded)
Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Additional Jurisdictional Restrictions (1)
Jurisdiction
Status
Max %
Product Type
UK
restricted
-
-
Expanded Dermal Absorption Data
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
Aggregated DA Values (5 records across 5 sources)
Type
DA %
Method
Skin Model
SCCS Ref
measured
57.0%
-
-
SCCP/0134
measured
0.214%
-
-
SCCP/0134
measured
0.214%
-
-
SCCS/0169
measured
11.8%
in_vitro
-
SCCS/0169
measured
50.0%
-
-
SCCS/0169
Additional Ingredient Properties
5 property records from structured ingredient metadata.
AntioxidantSoftener and conditionerBleaching agent
Regulatory Lists
Canada; consumer_product; Substances in Products - Canada (4/2014)Canada; Personal care; Substances in PCP - Canada (4/2014)Canada; pharmaceutical
Frequently Asked Questions
Is Arbutin (Alpha-Arbutin and Beta-Arbutin) safe in cosmetics?
Arbutin (Alpha-Arbutin and Beta-Arbutin) has a safety rating of "GOOD" in our database. EU status: restricted. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
Is Arbutin (Alpha-Arbutin and Beta-Arbutin) allowed in the EU?
Arbutin (Alpha-Arbutin and Beta-Arbutin) EU regulatory status: restricted. Maximum allowed concentration: 2% face / 0.5% body. This is based on EU Regulation 1223/2009 and its amendments.
What does Arbutin (Alpha-Arbutin and Beta-Arbutin) do in cosmetics?
Arbutin (Alpha-Arbutin and Beta-Arbutin) functions as: Skin Brightening. It is classified as a cosmetic ingredient in our database. CAS number: 497-76-7.
What is the NOAEL for Arbutin (Alpha-Arbutin and Beta-Arbutin)?
The NOAEL (No Observed Adverse Effect Level) for Arbutin (Alpha-Arbutin and Beta-Arbutin) is =0.0005 mg/kg bw/d based on a dermal absorption study via dermal route in rat. A total of 10 study endpoints are available. Source: SCCS Opinion.
Compliance Tools
Check Arbutin (Alpha-Arbutin and Beta-Arbutin) compliance across multiple jurisdictions:
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