Is Arginine HCl safe in cosmetics?
Arginine HCl has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
GOOD
Cosmetic Ingredient
Arginine HCl
Also known as: L-Arginine, hydrochloride (1:1), Arginine, monohydrochloride, L-, L-Arginine, monohydrochloride, Argamine, Arginine hydrochloride (+13 more)
INCI: ARGININE HCL
Arginine HCl (CAS 1119-34-2) is a cosmetic cosmetic ingredient functioning as Skin Conditioning. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
Function
Skin Conditioning
Editorial assessment
GOOD
Preliminary editorial note — not a computed safety verdict.
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR: Safe as used; α-amino acids and their salts reviewed
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Arginine HCl.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Editorial summary
Preliminary editorial summary for Arginine HCl — not a computed safety verdict. See the sourced toxicological data above.
Known Synonyms
L-Arginine, hydrochloride (1:1)
Arginine, monohydrochloride, L-
L-Arginine, monohydrochloride
Argamine
Arginine hydrochloride
Arginine monochloride
Arginine monohydrochloride
Argivene
Detoxargin
L-(+)-Arginine hydrochloride
L-Arginine hydrochloride
Levargin
Minophagen A
NSC 203450
NSC 7914
R-Gene
Tivortin
EINECS No.: 214-275-1
Chemical Function
Softener and conditioner
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
ARGININE HYDROCHLORIDE
ChEMBL ID
CHEMBL1200381
Max Phase
4
Adverse Event Associations
6
Frequently Asked Questions
Is Arginine HCl allowed in the EU?
Arginine HCl EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Arginine HCl do in cosmetics?
Arginine HCl functions as: Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 1119-34-2.
Is Arginine HCl used outside cosmetics?
Arginine HCl also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Arginine HCl compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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