Is BISPHENOL A BIS-ETHER safe in cosmetics?
BISPHENOL A BIS-ETHER has a safety rating of "GOOD" in our database. EU status: permitted. 3 toxicological study endpoint(s) are available in our database.
BISPHENOL A BIS-ETHER
Also known as: 2,2-Bis(p-(2-hydroxy-2-methylethoxy)phenyl)propane, 2,2-Bis(p-(beta-hydroxypropoxy)phenyl)propane, 2,2-Bis(p-(2-hydroxypropoxy)phenyl)propane, 2,2-Bis(4-(beta-hydroxypropoxy)phenyl)propane, 2,2-Bis(4-(2-hydroxypropoxy)phenyl)propane (+14 more)
BISPHENOL A BIS-ETHER (CAS 116-37-0) is a cosmetic cosmetic ingredient functioning as Not Reported. Reported NOAEL =75 mg/kg bw/day in Rabbit (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 116-37-0 →
Auto-generated CPSR Part A draft with source citations
Function
Not Reported
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
1-[4-[2-[4-(2-hydroxypropoxy)phenyl]propan-2-yl]phenoxy]propan-2-ol
InChIKey
MIUUNYUUEFHIHM-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Toxicological Studies
3 study endpoints found for BISPHENOL A BIS-ETHER. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =75 mg/kg bw/day | oral | Rabbit | developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =100 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =125 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Function Categories & List Membership
Cosmetic/Chemical Function Categories
No specific technical function
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for BISPHENOL A BIS-ETHER.
Regulatory Flags
cosing-sourced
eu-permitted
needs-enrichment
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to BISPHENOL A BIS-ETHER by CAS number or substance name.
Studies
3
Lowest NOAEL
75 mg/kg bw/day
Highest NOAEL
125 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
2,2-Bis(p-(2-hydroxy-2-methylethoxy)phenyl)propane
2,2-Bis(p-(beta-hydroxypropoxy)phenyl)propane
2,2-Bis(p-(2-hydroxypropoxy)phenyl)propane
2,2-Bis(4-(beta-hydroxypropoxy)phenyl)propane
2,2-Bis(4-(2-hydroxypropoxy)phenyl)propane
Bisphenol A bis(beta-hydroxypropyl) ether
Bisphenol A-propylene oxide adduct (1:2)
Dow Resin 565
EINECS 204-137-9
Hydroxypropylated diphenylolpropane
1,1'-(Isopropylidenebis(p-phenyleneoxy))di-2-propanol
Isopropylidenediphenoxypropanol
1,1'-((1-Methylethylidene)bis(4,1-phenyleneoxy))bis-2-propanol
NSC 408494
2-Propanol, 1,1'-isopropylidenebis(p-phenyleneoxy)di-
UNII-S5K2510L3D
2,2-Bis[4-(2-hydroxy-2-methylethoxy)phenyl]propane
Bisphenol A propoxylate
Bis-HPPP
Chemical Function
No specific technical function
Regulatory Lists
CEDI
Indirect additives food contact (10/2018)
Australian Status
AICIS status: listed
Frequently Asked Questions
Is BISPHENOL A BIS-ETHER allowed in the EU?
BISPHENOL A BIS-ETHER EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does BISPHENOL A BIS-ETHER do in cosmetics?
BISPHENOL A BIS-ETHER functions as: Not Reported. It is classified as a cosmetic ingredient in our database. CAS number: 116-37-0.
What is the NOAEL for BISPHENOL A BIS-ETHER?
The NOAEL (No Observed Adverse Effect Level) for BISPHENOL A BIS-ETHER is =75 mg/kg bw/day based on a developmental study via oral route in Rabbit. A total of 3 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is BISPHENOL A BIS-ETHER used outside cosmetics?
BISPHENOL A BIS-ETHER also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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