Poor Cosmetic Ingredient NOAEL Data

Potassium Cyanate

INCI: POTASSIUM CYANATE

CAS Number
590-28-3
Function
Skin Conditioning (Emollient), Hair Conditioning
Safety Rating
POOR

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status prohibited
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes No specific restriction; not CIR-reviewed as a standalone ingredient. Primary industrial use is as herbicide precursor.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

8 study endpoints found for Potassium Cyanate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 51 mg/kg bw/day oral monkey oral REACH
NOAEL >32.5 mg/kg bw/day 2011 mouse other REACH
NOAEL 300 mg/kg bw/day oral mouse oral REACH
NOAEL 53.5 mg/kg bw/day oral dog oral REACH
NOAEL 30 mg/kg bw/day oral dog oral REACH
LOAEL 150 mg/kg bw/day oral rat oral REACH
LOAEL 147 mg/kg bw/day oral rat oral REACH
NOAEL 50 mg/kg bw/day oral - oral REACH

Expert Verdict

Primary use is herbicide manufacturing, not cosmetics. Risk of hydrolysis under acidic conditions. Extremely limited use history in actual cosmetic products.

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Concern Level: High

Frequently Asked Questions

Is Potassium Cyanate safe in cosmetics?

Primary use is herbicide manufacturing, not cosmetics. Risk of hydrolysis under acidic conditions. Extremely limited use history in actual cosmetic products. The EU classifies Potassium Cyanate as "prohibited". Safety rating: POOR. 8 toxicological study endpoint(s) are available in our database.

Is Potassium Cyanate allowed in the EU?

Potassium Cyanate EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Potassium Cyanate do in cosmetics?

Potassium Cyanate functions as: Skin Conditioning (Emollient), Hair Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 590-28-3.

What is the Margin of Safety for Potassium Cyanate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Potassium Cyanate?

The NOAEL (No Observed Adverse Effect Level) for Potassium Cyanate is 51 mg/kg bw/day based on a oral study via oral route in monkey. A total of 8 study endpoints are available. Source: REACH.

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