Is Isopentanal safe in cosmetics?
Isopentanal has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Isopentanal
Also known as: Isovaleraldehyde, 4-01-00-03291, BRN 0773692, 1-Butanal, 3-methyl-, EINECS 209-691-5 (+15 more)
INCI: ISOPENTANAL
Isopentanal (CAS 590-86-3) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient. EU Regulation 1223/2009 status: permitted; GHS signal word DANGER. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 590-86-3 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Isopentanal is classified GHS Danger (H225, H317, H319, H335, H411, H315, H332) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Fragrance ingredient
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
3-methylbutanal
InChIKey
YGHRJJRRZDOVPD-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — FEMA GRAS; no specific CFR restriction for cosmetic use
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Isopentanal.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Signal Word
DANGER
Pictograms
FlamFlameCancerHealth haz
Hazard Statements
Highly flammable liquid and vapour Causes mild skin irritation Causes eye irritation May be harmful if swallowed and enters airways Toxic to aquatic life
Short-term Exposure Effects
The substance is irritating to the eyes and respiratory tract. The substance is mildly irritating to the skin. If swallowed the substance may cause vomiting and could result in aspiration pneumonitis.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 675 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
ICSC Safety Card
1748
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
The low molecular weight aldehydes, the halogenated aliphatic aldehydes, and the unsaturated aldehydes are particularly irritating. /Aldehydes/
Source: Hazardous Substances Data Bank (HSDB)
Regulatory (3)
JECFA Number
258
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
3-METHYLBUTYRALDEHYDE | 1997 | No safety concern at current levels of intake when used as a flavouring agent | TRS 884-JECFA 49/37 | FAS 40-JECFA 49/189
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
ISOVALERALDEHYDE | 1997 | No safety concern at current levels of intake when used as a flavouring agent | TRS 884-JECFA 49/37 | FAS 40-JECFA 49/189
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Flavouring and nutrient
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Isopentanal.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
Known Synonyms
Isovaleraldehyde
4-01-00-03291
BRN 0773692
1-Butanal, 3-methyl-
EINECS 209-691-5
FEMA No. 2692
2-Methylbutanal-4
3-Methylbutylaldehyde
beta-Methylbutyraldehyde
Aldehyde isovalerianique
UNII-69931RWI96
3-Methyl-Butanal
3-Methyl-Butyraldehyde
3-Methylbutan-1-al
Isoamyl aldehyde
Isopentaldehyde
Isovalerylaldehyde
Methyl butanal
b-Methylbutanal
beta-Methylbutanal
Chemical Function
Deodorizer
Fragrance
Flavouring and nutrient
Regulatory Lists
air; detected; emissions; Europe; Toys and children's products
air; detected; emissions; Europe; Other direct contact consumer goods
air; detected; emissions; Europe; Toys and children's products
Europe
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL18360
Frequently Asked Questions
Is Isopentanal allowed in the EU?
Isopentanal EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Isopentanal do in cosmetics?
Isopentanal functions as: Fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 590-86-3.
Is Isopentanal classified as hazardous under GHS?
Isopentanal carries a GHS signal word of "DANGER". Hazard statements: Highly flammable liquid and vapour Causes mild skin irritation Causes eye irritation May be harmful if swallowed and enters airways Toxic to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Is Isopentanal used outside cosmetics?
Isopentanal also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Isopentanal have different safety status in cosmetics vs industrial chemicals?
Isopentanal is classified GHS Danger (H225, H317, H319, H335, H411, H315, H332) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Isopentanal compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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