Good Cosmetic Ingredient NOAEL Data GHS Classified

BUTYROLACTONE

CAS Number

96-48-0

Function

Fragrance, Solvent

Safety Rating

GOOD

Regulatory Status

🇪🇺 EU Status Permitted

🇺🇸 US Status Not specifically regulated

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Toxicological Studies

8 study endpoints found for BUTYROLACTONE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint	Value	Route	Species	Study Type	Source
NOAEL	500 mg/kg bw/day	oral	rat	Developmental	COSMOS_DB
NOAEL	600 mg/kg bw/day	oral	rat	Short Term Toxicity	COSMOS_DB
NOAEL	350 mg/kg bw/day	oral	mouse	Short Term Toxicity	COSMOS_DB
NOAEL	900 mg/kg bw/day	oral	rat	Subchronic	COSMOS_DB
NOAEL	525 mg/kg bw/day	oral	mouse	Subchronic	COSMOS_DB
NOAEL	450 mg/kg bw/day	oral	rat	Carcinogenicity	COSMOS_DB
NOAEL	262 mg/kg bw/day	oral	mouse	Carcinogenicity	COSMOS_DB
dose_tested	500 mg/kg bw/day	oral	rat	Developmental	COSMOS_DB

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Signal Word

DANGER

Pictograms

corr; excl mark;warn

Hazard Statements

Harmful if swallowed Causes serious eye damage May cause drowsiness or dizziness Harmful to aquatic life

Short-term Exposure Effects

The substance is severely irritating to the eyes. Ingestion could cause effects on the central nervous system. This may result in excitement and central nervous system depression. Exposure at high concentrations could cause respiratory failure, convulsions and unconsciousness. See Notes.

Routes of Exposure

The substance can be absorbed into the body by inhalation of its vapour, by ingestion and through the skin.

Expert Verdict

BUTYROLACTONE is listed in the EU CosIng database with functions: Fragrance, Solvent It is permitted in the EU without specific restrictions.

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Concern Level: Low

Regulatory Flags

cosing-sourced eu-permitted fragrance needs-enrichment ifra_fragrance fda_food_additive

Frequently Asked Questions

Is BUTYROLACTONE safe in cosmetics?

BUTYROLACTONE is listed in the EU CosIng database with functions: Fragrance, Solvent It is permitted in the EU without specific restrictions. The EU classifies BUTYROLACTONE as "Permitted". Safety rating: GOOD. 8 toxicological study endpoint(s) are available in our database.

Is BUTYROLACTONE allowed in the EU?

BUTYROLACTONE EU regulatory status: Permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does BUTYROLACTONE do in cosmetics?

BUTYROLACTONE functions as: Fragrance, Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 96-48-0.

What is the NOAEL for BUTYROLACTONE?

The NOAEL (No Observed Adverse Effect Level) for BUTYROLACTONE is 500 mg/kg bw/day based on a Developmental study via oral route in rat. A total of 8 study endpoints are available. Source: COSMOS_DB.

Is BUTYROLACTONE classified as hazardous under GHS?

BUTYROLACTONE carries a GHS signal word of "DANGER". Hazard statements: Harmful if swallowed Causes serious eye damage May cause drowsiness or dizziness Harmful to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.

Compliance Tools

Check BUTYROLACTONE compliance across multiple jurisdictions:

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Ingredient Decoder

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82 Allergen Checker

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Substance Compliance

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MoS Calculator

Calculate Margin of Safety using SCCS methodology

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Heavy Metal Limits

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