Excellent Cosmetic Ingredient NOAEL Data GHS Classified

C10-11 Isoparaffin

INCI: C10-11 ISOPARAFFIN

CAS Number
64742-48-9
Function
solvent, viscosity controlling
Safety Rating
EXCELLENT

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes CIR: S - IJT 31(Suppl. 3):269-295, 2012

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Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

10 study endpoints found for C10-11 Isoparaffin. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL >=5000 mg/kg bw/day oral rat oral REACH
NOAEL >=5000 mg/kg bw/day oral - oral REACH
NOAEL >=200 2285 1995 rat inhalation REACH
NOAEL >=200 2285 inhalation - inhalation REACH
NOAEL >1000 mg/kg bw/day oral rat oral REACH
NOAEL >1000 mg/kg bw/day oral - oral REACH
NOAEL >=1000 mg/kg bw/day oral rat oral REACH
NOAEL >=1000 mg/kg bw/day oral - oral REACH
NOAEL >=6000 2106 1995 rat inhalation REACH
NOAEL >=6000 2106 inhalation - inhalation REACH

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Signal Word
DANGER
Pictograms
flam;flame; cancer;health haz
Hazard Statements
Flammable liquid and vapour May be fatal if swallowed and enters airways Toxic to aquatic life See Notes
Short-term Exposure Effects
The substance is mildly irritating to the eyes, skin and respiratory tract. The substance may cause effects on the central nervous system. Exposure to high concentrations of vapour could cause unconsciousness. If this liquid is swallowed, aspiration into the lungs may result in chemical pneumonitis. See Notes.
Long-term Exposure Effects
The substance defats the skin, which may cause dryness or cracking. See Notes.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its vapour and by ingestion.

Expert Verdict

Branched-chain aliphatic hydrocarbon with 10-11 carbons functioning as a solvent and viscosity-controlling agent. CIR Expert Panel concluded safe for cosmetic use with no genotoxic, reproductive, or developmental toxicity concerns. Used in eye makeup, skin care, and hair care products.

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Concern Level: None

Regulatory Flags

ifra_fragrance

Frequently Asked Questions

Is C10-11 Isoparaffin safe in cosmetics?

Branched-chain aliphatic hydrocarbon with 10-11 carbons functioning as a solvent and viscosity-controlling agent. CIR Expert Panel concluded safe for cosmetic use with no genotoxic, reproductive, or developmental toxicity concerns. Used in eye makeup, skin care, and hair care products. The EU classifies C10-11 Isoparaffin as "permitted". Safety rating: EXCELLENT. 10 toxicological study endpoint(s) are available in our database.

Is C10-11 Isoparaffin allowed in the EU?

C10-11 Isoparaffin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does C10-11 Isoparaffin do in cosmetics?

C10-11 Isoparaffin functions as: solvent, viscosity controlling. It is classified as a cosmetic ingredient in our database. CAS number: 64742-48-9.

What is the Margin of Safety for C10-11 Isoparaffin?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for C10-11 Isoparaffin?

The NOAEL (No Observed Adverse Effect Level) for C10-11 Isoparaffin is >=5000 mg/kg bw/day based on a oral study via oral route in rat. A total of 10 study endpoints are available. Source: REACH.

Is C10-11 Isoparaffin classified as hazardous under GHS?

C10-11 Isoparaffin carries a GHS signal word of "DANGER". Hazard statements: Flammable liquid and vapour May be fatal if swallowed and enters airways Toxic to aquatic life See Notes. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance โ€” at cosmetic use concentrations, hazard thresholds may not be met.

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