Is Calcium PCA safe in cosmetics?
Calcium PCA has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
Calcium PCA
Also known as: Calcium bis(5-oxo-L-prolinate), Calcium L-pidolate, 5-Oxo-L-proline calcium salt, Proline, 5-oxo-, calcium salt (2:1), L-, L-Proline, 5-oxo-, calcium salt (2:1)
INCI: CALCIUM PCA
Calcium PCA (CAS 31377-05-6) is a cosmetic cosmetic ingredient functioning as Skin conditioning agent — humectant. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 31377-05-6 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning agent — humectant
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
calcium bis((2S)-5-oxopyrrolidine-2-carboxylate)
InChIKey
YQFZERWESBDNRJ-QHTZZOMLSA-L
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Adequate — NOAEL 1000 mg/kg bw/day (oral, rat); dermal LD50 >2 g/kg; negligible systemic exposure at typical cosmetic use (≤0.2%)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Calcium PCA.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Humectant
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Calcium PCA.
Regulatory Flags
natural-origin
Known Synonyms
Calcium bis(5-oxo-L-prolinate)
Calcium L-pidolate
5-Oxo-L-proline calcium salt
Proline, 5-oxo-, calcium salt (2:1), L-
L-Proline, 5-oxo-, calcium salt (2:1)
Chemical Function
Humectant
Softener and conditioner
Frequently Asked Questions
Is Calcium PCA allowed in the EU?
Calcium PCA EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Calcium PCA do in cosmetics?
Calcium PCA functions as: Skin conditioning agent — humectant. It is classified as a cosmetic ingredient in our database. CAS number: 31377-05-6.
Is Calcium PCA used outside cosmetics?
Calcium PCA also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Calcium PCA compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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