Calcium PCA

INCI: CALCIUM PCA

CAS Number
31377-05-6
Function
Skin conditioning agent — humectant
Safety Rating
EXCELLENT

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Adequate — NOAEL 1000 mg/kg bw/day (oral, rat); dermal LD50 >2 g/kg; negligible systemic exposure at typical cosmetic use (≤0.2%)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Avoid formulation with nitrosating agents due to N-nitroso compound formation risk; PCA is a natural skin component (NMF); typical use ≤0.2% in leave-on formulations.

⚠️
Concern Level: Low

Regulatory Flags

natural-origin

Frequently Asked Questions

Is Calcium PCA safe in cosmetics?

Avoid formulation with nitrosating agents due to N-nitroso compound formation risk; PCA is a natural skin component (NMF); typical use ≤0.2% in leave-on formulations. The EU classifies Calcium PCA as "permitted". Safety rating: EXCELLENT.

Is Calcium PCA allowed in the EU?

Calcium PCA EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Calcium PCA do in cosmetics?

Calcium PCA functions as: Skin conditioning agent — humectant. It is classified as a cosmetic ingredient in our database. CAS number: 31377-05-6.

What is the Margin of Safety for Calcium PCA?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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