Is Calcium Sulfate safe in cosmetics?
Calcium Sulfate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Calcium Sulfate
Also known as: Sulfuric acid, calcium salt (1:1), calcium sulphate, Anhydrous sulfate of lime, Caswell No. 152, EINECS 231-900-3 (+13 more)
INCI: CALCIUM SULFATE
Calcium Sulfate (CAS 7778-18-9) is a cosmetic cosmetic ingredient functioning as Abrasive, Bulking, Opacifying. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 7778-18-9 →
Auto-generated CPSR Part A draft with source citations
Function
Abrasive, Bulking, Opacifying
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
calcium sulfate
InChIKey
OSGAYBCDTDRGGQ-UHFFFAOYSA-L
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
GRAS for food use under 21 CFR 184.1230. JECFA assigns no specific ADI—considered non-toxic at typical dietary levels. CIR reviewed as part of inorganic sulfates assessment (2014).
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Calcium Sulfate.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Hazard Statements
No hazard classification according to GHS criteria
Short-term Exposure Effects
May cause mechanical irritation. Ingestion could cause gastrointestinal blockage.
Long-term Exposure Effects
Lungs may be affected by repeated or prolongated exposure to dust particles if crystalline silica is present.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10,000,000 - 100,000,000 tonnes
Substance Type
SUBSTANCE; GROUP
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| ASEAN | permitted_colorant | - | All products |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
ICSC Safety Card
1589
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Regulatory (2)
JECFA Evaluation
CALCIUM SULFATE | 1973 | NOT LIMITED | NMRS 53/TRS 539-JECFA 17/37 | FAS 5/NMRS 53A-JECFA 17/415
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
EU Food Improvement
Food additives
Source: EU Food Improvement Agents
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Abrasive
Anti-caking agent
Binder
Catalyst
Degradant/impurity
Drier
Dye
Filler
Flavouring and nutrient
Leavening agent
Regulatory List Membership (3)
EU Regulated in Personal Care
FDA Substances Added to Food (EAFUS)
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Calcium Sulfate.
Regulatory Flags
fda_food_additive
eu_cosing_listed
jecfa_safe
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Calcium Sulfate by CAS number or substance name.
Studies
15
Lowest NOAEL
79 mg/kg bw/day
Highest NOAEL
1600 mg/kg bw/day
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
Sulfuric acid, calcium salt (1:1)
calcium sulphate
Anhydrous sulfate of lime
Caswell No. 152
EINECS 231-900-3
EPA Pesticide Chemical Code 005602
Karstenite
Muriacite
Natural anhydrite
NSC 529649
Satin White
Surfuric acid calcium(2+) salt (1:1)
Calcium sulfuricum
UNII-E934B3V59H
Calcium sulfate anhydrous
Calcarea sulphurica 30C
CaSO4
Kalziumsulfat
Chemical Function
Abrasive
Dye
Opacifer
Filler
Pigment
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
inert_ingredient; non_food_use; Pesticides
Europe; plastic_additive
Europe; Personal care
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Canada; pharmaceutical
active_ingredient; animal_products; Europe; pharmaceutical; residue
Europe; supplements
Europe; food_additive; supplements
inert_ingredient; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
CALCIUM SULFATE
ChEMBL ID
CHEMBL2106140
Max Phase
-1
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Calcium sulfate
E Number
E516
ADI
NOT LIMITED mg/kg bw
Food Category
preservative
Frequently Asked Questions
Is Calcium Sulfate allowed in the EU?
Calcium Sulfate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Calcium Sulfate do in cosmetics?
Calcium Sulfate functions as: Abrasive, Bulking, Opacifying. It is classified as a cosmetic ingredient in our database. CAS number: 7778-18-9.
Is Calcium Sulfate used outside cosmetics?
Calcium Sulfate also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Calcium Sulfate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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(APPLE/CITRUS JUNOS/LENTIL/PEAR/PUMPKIN/STRAWBERRY/TOMATO FRUIT)/CORN KERNEL/(ARCTIUM LAPPA/BRASSICA OLERACEA ACEPHALA/CABBAGE/CAMELLIA SINENSIS/MORINGA OLEIFERA/RADISH/SPINACH LEAF)/(SORGHUM BICOLOR LEAF/STEM)/OAT MEAL/POTATO PULP/(CARROT/NELUMBO NUCIFERA/RADISH/WILD YAM ROOT)/(AMARANTHUS HYPOCHONDRIACUS/CASHEW/CICER ARIETINUM/COIX LACRYMA-JOBI MA-YUEN /MACADAMIA TERNIFOLIA/PHASEOLUS ANGULARIS/PISTACIA VERA/RHYNCHOSIA NULUBILIS/RICE/SESAME/SETARIA ITALICA/SOYBEAN/SWEET ALMOND/WHEAT SEED)/HORDEUM VULGARE SPROUT/CYPERUS ESCULENTUS TUBER/ARTEMISIA PRINCEPS/BROCCOLI/CHENOPODIUM QUINOA/ENTEROMORPHA COMPRESSA/HORDEUM VULGARE/IPOMOEA BATATAS/LAMINARIA JAPONICA/LENTINUS EDODES/PLEUROTUS OSTREATUS/PORPHYRA TENERA/UNDARIA PINNATIFIDA EXTRACT
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Chemical family
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Potassium Sulfate
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Chemical family
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