Is CI 77231 safe in cosmetics?
CI 77231 has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
CI 77231
Also known as: Sulfuric acid, calcium salt (1:1), calcium sulphate, Calcium sulfate, Anhydrous sulfate of lime, Caswell No. 152 (+14 more)
CI 77231 (CAS 7778-18-9) is a cosmetic cosmetic ingredient functioning as Colorant (white opacifier), Bulking agent, Absorbent. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 7778-18-9 →
Auto-generated CPSR Part A draft with source citations
Function
Colorant (white opacifier), Bulking agent, Absorbent
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
calcium sulfate
InChIKey
OSGAYBCDTDRGGQ-UHFFFAOYSA-L
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not separately listed as an FDA color additive; used as a cosmetic ingredient
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for CI 77231.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Hazard Statements
No hazard classification according to GHS criteria
Short-term Exposure Effects
May cause mechanical irritation. Ingestion could cause gastrointestinal blockage.
Long-term Exposure Effects
Lungs may be affected by repeated or prolongated exposure to dust particles if crystalline silica is present.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10,000,000 - 100,000,000 tonnes
Substance Type
SUBSTANCE; GROUP
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| ASEAN | permitted_colorant | - | All products |
Additional Ingredient Properties
1 property record from structured ingredient metadata.
colorant
{"Common_Name": "Bismuth Citrate", "Chemical_Name": "Bismuth citrate", "CAS_Number": "813-93-4", "Colorant_Type": "Inorganic Pigment", "Approved_Uses": "All cosmetics", "Max_Concentration_%": "No limit", "EU_Status": "Approved", "US_FDA_Status": "Approved", "Notes": "Pearl effect"}
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
ICSC Safety Card
1589
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Regulatory (2)
JECFA Evaluation
CALCIUM SULFATE | 1973 | NOT LIMITED | NMRS 53/TRS 539-JECFA 17/37 | FAS 5/NMRS 53A-JECFA 17/415
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
EU Food Improvement
Food additives
Source: EU Food Improvement Agents
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Abrasive
Anti-caking agent
Binder
Catalyst
Degradant/impurity
Drier
Dye
Filler
Flavouring and nutrient
Leavening agent
Regulatory List Membership (3)
EU Regulated in Personal Care
FDA Substances Added to Food (EAFUS)
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for CI 77231.
Regulatory Flags
colorant
fda_food_additive
eu_cosing_listed
Known Synonyms
Sulfuric acid, calcium salt (1:1)
calcium sulphate
Calcium sulfate
Anhydrous sulfate of lime
Caswell No. 152
EINECS 231-900-3
EPA Pesticide Chemical Code 005602
Karstenite
Muriacite
Natural anhydrite
NSC 529649
Satin White
Surfuric acid calcium(2+) salt (1:1)
Calcium sulfuricum
UNII-E934B3V59H
Calcium sulfate anhydrous
Calcarea sulphurica 30C
CaSO4
Kalziumsulfat
Chemical Function
Abrasive
Dye
Opacifer
Filler
Pigment
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
inert_ingredient; non_food_use; Pesticides
Europe; plastic_additive
Europe; Personal care
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Canada; pharmaceutical
active_ingredient; animal_products; Europe; pharmaceutical; residue
Europe; supplements
Europe; food_additive; supplements
inert_ingredient; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
CALCIUM SULFATE
ChEMBL ID
CHEMBL2106140
Max Phase
-1
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Calcium sulfate
E Number
E516
ADI
NOT LIMITED mg/kg bw
Food Category
preservative
Frequently Asked Questions
Is CI 77231 allowed in the EU?
CI 77231 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does CI 77231 do in cosmetics?
CI 77231 functions as: Colorant (white opacifier), Bulking agent, Absorbent. It is classified as a cosmetic ingredient in our database. CAS number: 7778-18-9.
Is CI 77231 used outside cosmetics?
CI 77231 also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check CI 77231 compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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Calcium Hypochlorite
Poor
Chemical family
Oxidizing agent
Calcium Sulfate
Good
Chemical family
Abrasive, Bulking, Opacifying
Potassium Sulfate
Excellent
Chemical family
Viscosity controlling
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