Moderate Cosmetic Ingredient NOAEL Data GHS Classified

Candelilla Wax (Euphorbia Cerifera Wax) Comprehen

CAS Number
8002-74-2
Function
Abrasive; Adhesion/cohesion promoter; Anti-adhesive/cohesive; Anti-static agent; Antioxidant; Binder; Chemical reaction regulator; Cleaning agent; Defoamer; Deodorizer; Diluent; Dispersing agent; Emulsifier; Film former; Flavouring and nutrient; Flow promoter; Fragrance; Fuel; Hardener; Humectant; Lubricating agent; Processing aids not otherwise specified; Softener and conditioner; Stabilizing agent; Surface modifier; Surfactant (surface active agent); Thickening agent; Viscosity modifier; Waterproofing agent; Wetting agent (non-aqueous)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

10 study endpoints found for Candelilla Wax (Euphorbia Cerifera Wax) Comprehen. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 1000 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
NOAEL 1000 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
NOAEL 2 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 17 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 17 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 1815 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 1815 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 160 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 157 mg/kg bw/day oral rat Subchronic COSMOS_DB
dose_tested 1000 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects
The fume is irritating to the eyes, nose and throat.
Routes of Exposure
The substance can be absorbed into the body by inhalation of fume.

Expert Verdict

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Concern Level: Low

Regulatory Flags

ifra_fragrance fda_food_additive jecfa_concern

Frequently Asked Questions

Is Candelilla Wax (Euphorbia Cerifera Wax) Comprehen safe in cosmetics?

Candelilla Wax (Euphorbia Cerifera Wax) Comprehen has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 10 toxicological study endpoint(s) are available in our database.

Is Candelilla Wax (Euphorbia Cerifera Wax) Comprehen allowed in the EU?

Candelilla Wax (Euphorbia Cerifera Wax) Comprehen EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Candelilla Wax (Euphorbia Cerifera Wax) Comprehen do in cosmetics?

Candelilla Wax (Euphorbia Cerifera Wax) Comprehen functions as: Abrasive; Adhesion/cohesion promoter; Anti-adhesive/cohesive; Anti-static agent; Antioxidant; Binder; Chemical reaction regulator; Cleaning agent; Defoamer; Deodorizer; Diluent; Dispersing agent; Emulsifier; Film former; Flavouring and nutrient; Flow promoter; Fragrance; Fuel; Hardener; Humectant; Lubricating agent; Processing aids not otherwise specified; Softener and conditioner; Stabilizing agent; Surface modifier; Surfactant (surface active agent); Thickening agent; Viscosity modifier; Waterproofing agent; Wetting agent (non-aqueous). It is classified as a Cosmetic Ingredient in our database. CAS number: 8002-74-2.

What is the Margin of Safety for Candelilla Wax (Euphorbia Cerifera Wax) Comprehen?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Candelilla Wax (Euphorbia Cerifera Wax) Comprehen?

The NOAEL (No Observed Adverse Effect Level) for Candelilla Wax (Euphorbia Cerifera Wax) Comprehen is 1000 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.

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