Is Catalase Cosmetic Ingredient safe in cosmetics?
Catalase Cosmetic Ingredient has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
Catalase Cosmetic Ingredient
Also known as: EINECS 232-577-1
INCI: CATALASE
Catalase Cosmetic Ingredient (CAS 9001-05-2) is a cosmetic antioxidant functioning as Antioxidant enzyme that catalyzes the breakdown of hydrogen peroxide in. NOAEL 1000 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 9001-05-2 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Catalase Cosmetic Ingredient is classified GHS Danger (H334) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Antioxidant enzyme that catalyzes the breakdown of hydrogen peroxide in cosmetic formulations
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No specific restrictions
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Catalase Cosmetic Ingredient.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Catalase Cosmetic Ingredient. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =1000 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =1289 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Catalase Cosmetic Ingredient across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex II — Prohibited
Ref: 74
(EC) 2009/1223
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (II - Prohibited)
BRIN Brazil/India Cosmetics
Brazil: Prohibited
India: Prohibited (GNRAS)
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CA | restricted | No concentration limit stated | All cosmetics |
Additional Ingredient Properties
3 property records from structured ingredient metadata.
anti_aging
{"anti_aging_claim": "antioxidant-protection", "mechanism_of_action": "Enzymatic activity, targeted protein modification", "target_skin_layer": "epidermis, dermis", "collagen_stimulation": "Moderate", "elastin_protection": "Moderate", "wrinkle_reduction_pct": "8-15", "clinical_study_duration_weeks": "8", "sample_size": "25", "double_blind": "No", "placebo_controlled": "Yes", "published_journal": "…
anti_pollution
{"cas_number": "9001-05-2", "ingredient_class": "antioxidant_pollution_shield", "primary_mechanism": "direct_scavenging", "pollution_types_targeted": "PM2_5/oxidative_stress", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathwa…
baby_pediatric
{"cas_number": "CAS-FUNC-35", "ingredient_class": "other", "pediatric_safety_rating": "good", "minimum_age_months": "3", "neonatal_safe": "no", "premature_infant_safe": "insufficient_data", "skin_barrier_maturity_consideration": "Functional ingredient - generally safe", "transepidermal_absorption_risk_pediatric": "low", "systemic_exposure_concern_pediatric": "low", "dose_per_kg_body_weight_concern…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Chemical reaction regulator
Cleaning agent
Softener and conditioner
Stabilizing agent
Regulatory List Membership (3)
EU Banned in Cosmetics
EPA Safer Chemical Ingredients List (SCIL)
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Catalase Cosmetic Ingredient.
Regulatory Flags
Allergen
eu_banned_cosmetics
epa_safer_alternative
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Catalase Cosmetic Ingredient by CAS number or substance name.
Studies
8
Lowest NOAEL
1000 mg/kg bw/day
Highest NOAEL
1289 mg/kg bw/day
ToxValDB_ECHA_IUCLID
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
EINECS 232-577-1
Chemical Function
Cleaning agent
Softener and conditioner
Chemical reaction regulator
Stabilizing agent
Regulatory Lists
SCIL (9/2019)
banned; Europe; Personal care
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Catalase Cosmetic Ingredient allowed in the EU?
Catalase Cosmetic Ingredient EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Catalase Cosmetic Ingredient do in cosmetics?
Catalase Cosmetic Ingredient functions as: Antioxidant enzyme that catalyzes the breakdown of hydrogen peroxide in cosmetic formulations. It is classified as a Antioxidant in our database. CAS number: 9001-05-2.
What is the NOAEL for Catalase Cosmetic Ingredient?
The NOAEL (No Observed Adverse Effect Level) for Catalase Cosmetic Ingredient is =1000 mg/kg bw/day based on a subchronic study via oral route in Rat. A total of 2 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Catalase Cosmetic Ingredient used outside cosmetics?
Catalase Cosmetic Ingredient also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Catalase Cosmetic Ingredient have different safety status in cosmetics vs industrial chemicals?
Catalase Cosmetic Ingredient is classified GHS Danger (H334) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Catalase Cosmetic Ingredient compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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