Alpha-Isomethyl Ionone
INCI: ALPHA-ISOMETHYL IONONE
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Alpha-Isomethyl Ionone. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 4.1 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| dose_tested | 4.1 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
Sensitization Profile
Contact sensitization data for Alpha-Isomethyl Ionone based on clinical patch test studies and IFRA standards.
Source: ESSCA/IVDK
Dermal Penetration Profile
Skin absorption and penetration characteristics of Alpha-Isomethyl Ionone, relevant to systemic exposure and MoS calculations.
Source: SCCS/1459/11, IFRA
Expert Verdict
Good safety profile. Generally considered safe for cosmetic use.
Regulatory Flags
Frequently Asked Questions
Is Alpha-Isomethyl Ionone safe in cosmetics?
Good safety profile. Generally considered safe for cosmetic use. The EU classifies Alpha-Isomethyl Ionone as "permitted". Safety rating: GOOD. 2 toxicological study endpoint(s) are available in our database.
Is Alpha-Isomethyl Ionone allowed in the EU?
Alpha-Isomethyl Ionone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Alpha-Isomethyl Ionone do in cosmetics?
Alpha-Isomethyl Ionone functions as: Fragrance ingredient. It is classified as a Fragrance in our database. CAS number: 127-51-5.
What is the Margin of Safety for Alpha-Isomethyl Ionone?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Alpha-Isomethyl Ionone?
The NOAEL (No Observed Adverse Effect Level) for Alpha-Isomethyl Ionone is 4.1 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
Check Alpha-Isomethyl Ionone compliance across multiple jurisdictions:
Related Ingredients
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