Cinnamoyl Tryptamine

INCI: CINNAMOYL TRYPTAMINE

CAS Number
Not publicly assigned (novel/research-grade compound)
Function
Skin conditioning; reported bioactivity as melanogenesis modulator and antioxidant in research literature
Safety Rating
POOR

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Not reviewed by CIR. No FDA restriction, but responsibility falls on manufacturer to substantiate safety per FD&C Act 601.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Novel research-grade compound with major data gaps. α,β-Unsaturated carbonyl structure presents alerts for skin sensitization and genotoxicity. Tryptamine backbone raises concerns about neuroactive potential at systemic exposure. Comprehensive toxicological package including genotoxicity, repeat dose, sensitization, and reproductive toxicity studies required before cosmetic use. Not suitable for CPSR without sponsored testing.

⚠️
Concern Level: High

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Cinnamoyl Tryptamine safe in cosmetics?

Novel research-grade compound with major data gaps. α,β-Unsaturated carbonyl structure presents alerts for skin sensitization and genotoxicity. Tryptamine backbone raises concerns about neuroactive potential at systemic exposure. Comprehensive toxicological package including genotoxicity, repeat dose, sensitization, and reproductive toxicity studies required before cosmetic use. Not suitable for CPSR without sponsored testing. The EU classifies Cinnamoyl Tryptamine as "permitted". Safety rating: POOR.

Is Cinnamoyl Tryptamine allowed in the EU?

Cinnamoyl Tryptamine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Cinnamoyl Tryptamine do in cosmetics?

Cinnamoyl Tryptamine functions as: Skin conditioning; reported bioactivity as melanogenesis modulator and antioxidant in research literature. It is classified as a cosmetic ingredient in our database. CAS number: Not publicly assigned (novel/research-grade compound).

What is the Margin of Safety for Cinnamoyl Tryptamine?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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