Is Cinoxate safe in cosmetics?
Cinoxate has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted.
Moderate
Cosmetic Ingredient
Cinoxate
Also known as: 2-Ethoxylethyl-p-methoxycinnamate, BRN 2728232, Caswell No. 427E, EINECS 203-191-0, EPA Pesticide Chemical Code 076604 (+6 more)
INCI: CINOXATE
Cinoxate (CAS 104-28-9) is a cosmetic cosmetic ingredient functioning as UV Filter (UVB absorber, peak at 289 nm). EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 104-28-9 →
Auto-generated CPSR Part A draft with source citations
Function
UV Filter (UVB absorber, peak at 289 nm)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2-ethoxyethyl (E)-3-(4-methoxyphenyl)prop-2-enoate
InChIKey
CMDKPGRTAQVGFQ-RMKNXTFCSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
FDA-approved OTC sunscreen active at ≤3% concentration; however, FDA has not determined GRAS status due to insufficient safety data
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Cinoxate.
Calculate MoS for your specific formulation with the MoS Calculator.
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
KR Korea MFDS Annex 2 (Restricted)
Category: UV Filter. Max: 5%.
JPKR Japan/Korea Cosmetics
Japan (Positive (UV Absorber)): max 5.0
Japan (Restricted): max Wash-away: No limit | Leave-on: 5.0% | Mucosa: 5.0%
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| JP | restricted | Wash-away: No limit | Leave-on: 5.0% | Mucosa: 5.0% | Wash-away: No limit | Leave-on: 5.0% | Mucosa: 5.0% |
Additional Ingredient Properties
1 property record from structured ingredient metadata.
sunscreen_uv
{"cas_number": "104-28-9", "uv_filter_type": "organic_UVB", "chemical_class": "cinnamate", "absorption_spectrum_nm_range": "270-328", "peak_absorption_wavelength_nm": "289", "molar_extinction_coefficient": "18500", "critical_wavelength_nm": "312", "UVA_PF": "negligible", "SPF_contribution_per_percent": "4.2", "photostability_rating": "moderate", "photodegradation_half_life_hours": "4.0", "photosta…
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Skin Eye Respiratory Irritation
Derivatives of PABA, benzophenone, cinnamic acid, and salicylate and 2-phenylbenzimidazole-5-sulfonic acid have caused skin irritation including burning, stinging, pruritus, and erythema on rare occasions. /Sunscreens/
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
UV stabilizer
Expert Verdict
Expert safety assessment and concern-level summary for Cinoxate.
Known Synonyms
2-Ethoxylethyl-p-methoxycinnamate
BRN 2728232
Caswell No. 427E
EINECS 203-191-0
EPA Pesticide Chemical Code 076604
Giv Tan f
Give-Tan
Sundare
Cinoxato
Cinoxatum
UNII-5437O7N5BH
Chemical Function
UV stabilizer
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
pharmaceutical
Canada; pharmaceutical
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
CINOXATE
ChEMBL ID
CHEMBL2104045
Max Phase
2
Frequently Asked Questions
Is Cinoxate allowed in the EU?
Cinoxate EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Cinoxate do in cosmetics?
Cinoxate functions as: UV Filter (UVB absorber, peak at 289 nm). It is classified as a cosmetic ingredient in our database. CAS number: 104-28-9.
Is Cinoxate used outside cosmetics?
Cinoxate also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Cinoxate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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