Is cis-Jasmone safe in cosmetics?
cis-Jasmone has a safety rating of "EXCELLENT" in our database. EU status: restricted. US status: permitted.
EXCELLENT
Cosmetic Ingredient
cis-Jasmone
Also known as: 4-07-00-00337, BRN 1907713, EINECS 207-668-4, FEMA No. 3196, 3-Methyl-2-(cis-2-penten-1-yl)-2-cyclopenten-1-one (+2 more)
INCI: CIS-JASMONE
cis-Jasmone (CAS 488-10-8) is a cosmetic cosmetic ingredient functioning as Fragrance (jasmine floral note). EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
Function
Fragrance (jasmine floral note)
Editorial assessment
EXCELLENT
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
3-methyl-2-[(Z)-pent-2-enyl]cyclopent-2-en-1-one
InChIKey
XMLSXPIVAXONDL-PLNGDYQASA-N
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
RIFM assessed — safe as described; IFRA 51st Amendment compliant at up to 100% in non-skin contact applications
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for cis-Jasmone.
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
NESIL
5400 µg/cm²
GHS: 1B
Human: positive
Source: HPPT: [596] Epstein WL (1977): Report to RIFM, 25 February and 19 April, unpublished.
HRIPT Human Patch Test Studies
3 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 5400 | - | - |
| HRIPT | - | 0 | 620 | - | - |
| HRIPT | - | 0 | - | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Skin Eye Respiratory Irritation
A skin irritant.
Source: Hazardous Substances Data Bank (HSDB)
Regulatory (2)
JECFA Number
1114
Source: WHO/JECFA
JECFA Evaluation
3-METHYL-2-(2-PENTENYL)-2-CYCLOPENTEN-1-ONE | 2016 | No safety concern at current levels of intake when used as a flavouring agent | ">TRS 1000-JECFA 82/126 | FAS 50-JECFA 59/331
Source: WHO/JECFA
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (4)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Editorial summary
Preliminary editorial summary for cis-Jasmone — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
potential-allergen
fragrance-component
epa_safer_alternative
ifra_fragrance
fda_food_additive
Known Synonyms
4-07-00-00337
BRN 1907713
EINECS 207-668-4
FEMA No. 3196
3-Methyl-2-(cis-2-penten-1-yl)-2-cyclopenten-1-one
3-Methyl-2-(2-pentenyl)-2-cyclopenten-1-one, (Z)-
UNII-RC4W0G9YUK
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
consumer_product
Europe
IFRA Transparency
SCIL (9/2019)
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
CIS-JASMONE
ChEMBL ID
CHEMBL2251602
Frequently Asked Questions
Is cis-Jasmone allowed in the EU?
cis-Jasmone EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does cis-Jasmone do in cosmetics?
cis-Jasmone functions as: Fragrance (jasmine floral note). It is classified as a cosmetic ingredient in our database. CAS number: 488-10-8.
Is cis-Jasmone used outside cosmetics?
cis-Jasmone also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check cis-Jasmone compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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