Moderate Cosmetic Ingredient

Glucamine

INCI: GLUCAMINE

CAS Number
488-43-7 (D-glucamine)
Function
Skin conditioning
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted — not restricted under 21 CFR; no CIR monograph

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

ECHA C&L notifications report H315 (skin irritation) and H319 (serious eye irritation) from 2 of 3 notifiers. Not to be confused with Glucosamine (CIR-reviewed, different CAS). No CIR monograph for Glucamine itself. No HRIPT data, no dermal penetration studies, no MoS calculation identified. Use near eyes contraindicated without further testing.

⚠️
Concern Level: Moderate

Frequently Asked Questions

Is Glucamine safe in cosmetics?

ECHA C&L notifications report H315 (skin irritation) and H319 (serious eye irritation) from 2 of 3 notifiers. Not to be confused with Glucosamine (CIR-reviewed, different CAS). No CIR monograph for Glucamine itself. No HRIPT data, no dermal penetration studies, no MoS calculation identified. Use near eyes contraindicated without further testing. The EU classifies Glucamine as "permitted". Safety rating: MODERATE.

Is Glucamine allowed in the EU?

Glucamine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Glucamine do in cosmetics?

Glucamine functions as: Skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 488-43-7 (D-glucamine).

What is the Margin of Safety for Glucamine?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Glucamine compliance across multiple jurisdictions:

🔬
Ingredient Decoder
Paste a full ingredient list for instant analysis
 🌸
82 Allergen Checker
Check for EU declarable fragrance allergens
 🧪
Substance Compliance
Check compliance across 55 jurisdictions
 🧮
MoS Calculator
Calculate Margin of Safety using SCCS methodology
 ⚗️
Heavy Metal Limits
Compare limits across jurisdictions

Related Ingredients

Catharanthus Roseus Callus Conditioned Media
Moderate
Phialophora Parasitica/Aquilaria Agallocha Wood Ferment Powder
Moderate
Saccharomyces/Hydrolyzed Rice Bran Ferment Extract Filtrate
Good
Rosa Centifolia Extract
Moderate
Decapeptide-33
Moderate
Browse all 30,000+ ingredients →
📱

Is Glucamine in Your Products?

Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free →

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Glucamine in your formulation.

Ingredient Decoder MoS Calculator