Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Citronellal Dimethyl Acetal. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 1500 mg/kg bw/day | oral | mouse | Immunotoxicology | COSMOS_DB |
| dose_tested | 1500 mg/kg bw/day | oral | mouse | Immunotoxicology | COSMOS_DB |
Expert Verdict
Potential hydrolysis to citronellal under acidic conditions (pH <4) may regenerate the allergen in situ; not expected to be phototoxic or photoallergenic per RIFM; monitor formulation pH to prevent acetal hydrolysis
Regulatory Flags
Frequently Asked Questions
Is Citronellal Dimethyl Acetal safe in cosmetics?
Potential hydrolysis to citronellal under acidic conditions (pH <4) may regenerate the allergen in situ; not expected to be phototoxic or photoallergenic per RIFM; monitor formulation pH to prevent acetal hydrolysis The EU classifies Citronellal Dimethyl Acetal as "prohibited". Safety rating: GOOD. 2 toxicological study endpoint(s) are available in our database.
Is Citronellal Dimethyl Acetal allowed in the EU?
Citronellal Dimethyl Acetal EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Citronellal Dimethyl Acetal do in cosmetics?
Citronellal Dimethyl Acetal functions as: Fragrance ingredient (floral/green note modifier). It is classified as a cosmetic ingredient in our database. CAS number: 7549-37-3.
What is the Margin of Safety for Citronellal Dimethyl Acetal?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Citronellal Dimethyl Acetal?
The NOAEL (No Observed Adverse Effect Level) for Citronellal Dimethyl Acetal is 1500 mg/kg bw/day based on a Immunotoxicology study via oral route in mouse. A total of 2 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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