Is Citronellyl Butyrate safe in cosmetics?
Citronellyl Butyrate has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Citronellyl Butyrate
Also known as: Butanoic acid, 3,7-dimethyl-6-octen-1-yl ester, 6-Octen-1-ol, 3,7-dimethyl-, butyrate, 2-02-00-00248, BRN 1707201, Butyric acid, 3,7-dimethyl-6-octenyl ester (+14 more)
Citronellyl Butyrate (CAS 141-16-2) is a cosmetic cosmetic ingredient functioning as Flavouring and nutrient; Fragrance. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 141-16-2 →
Auto-generated CPSR Part A draft with source citations
Function
Flavouring and nutrient; Fragrance
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
3,7-dimethyloct-6-enyl butanoate
InChIKey
XQPZQXTWYZAXAK-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Citronellyl Butyrate.
Calculate MoS for your specific formulation with the MoS Calculator.
HRIPT Human Patch Test Studies
2 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HRIPT | 102 | 0 | 6495 | 6495 | non-sensitizer |
| HMT | - | 0 | 3240 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
65
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
CITRONELLYL BUTYRATE | 2002 | No safety concern at current levels of intake when used as a flavouring agent | Secondary components do not raise a safety concern | TRS 913-JECFA 59/111 | FAS 40-JECFA 49/329 (1997)
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Citronellyl Butyrate.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
jecfa_safe
Known Synonyms
Butanoic acid, 3,7-dimethyl-6-octen-1-yl ester
6-Octen-1-ol, 3,7-dimethyl-, butyrate
2-02-00-00248
BRN 1707201
Butyric acid, 3,7-dimethyl-6-octenyl ester
Butyric acid, ester with citronellol
Citronellyl butanoate
Citronellyl n-butyrate
2,6-Dimethyl-2-octen-8-ol, butyrate
3,7-Dimethyl-6-octenyl butanoate
2,6-Dimethyl-2-octen-8-yl butyrate
3,7-Dimethyl-6-octen-1-yl butyrate
EINECS 205-463-4
EINECS 278-467-7
FEMA No. 2312
Natural rhodinol, butylated
NSC 46147
3,7-Dimethyl-6-octenyl butyrate
UNII-IY68QPD54V
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3185221
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
CITRONELLYL BUTYRATE
ADI
No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
Food Category
flavoring
Frequently Asked Questions
Is Citronellyl Butyrate allowed in the EU?
Citronellyl Butyrate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Citronellyl Butyrate do in cosmetics?
Citronellyl Butyrate functions as: Flavouring and nutrient; Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 141-16-2.
Is Citronellyl Butyrate used outside cosmetics?
Citronellyl Butyrate also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Citronellyl Butyrate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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