Is D&C Red No. 7 safe in cosmetics?
D&C Red No. 7 has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
GOOD
Colorant
D&C Red No. 7
Also known as: 2-Naphthalenecarboxylic acid, 3-hydroxy-4-[(4-methyl-2-sulfophenyl)azo]-, calcium salt (1:1), Brilliant Carmine 6B, Lithol Rubine BCA, Calcium 3-hydroxy-4-[(4-methyl-2-sulfonatophenyl)diazenyl]naphthalene-2-carboxylate, 2-Naphthalenecarboxylic acid, 3-hydroxy-4-[2-(4-methyl-2-sulfophenyl)diazenyl]-, calcium salt (1:1) (+4 more)
INCI: D&C RED NO. 7
D&C Red No. 7 (CAS 5281-04-9) is a cosmetic colorant functioning as colorant. EU Regulation 1223/2009 status: permitted, max 0.4% max in non-oxidative hair dyes. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
Function
colorant
Editorial assessment
GOOD
Preliminary editorial note — not a computed safety verdict.
Regulatory Status
EU EU Status
permitted
EU Max Conc.
0.4% max in non-oxidative hair dyes
US US Status
permitted
US Notes
Permitted for coloring cosmetics generally per 21 CFR 74.2307; prohibited for eye area use; FDA batch certification required per 21 CFR Part 80.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for D&C Red No. 7.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10,000 - 100,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| BR | permitted_colorant | - | Column 3: Not near mucous membranes |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Pigment
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Editorial summary
Preliminary editorial summary for D&C Red No. 7 — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
batch-certification-required
eye-area-prohibited
annex-iv-permitted
sccs-reviewed
color-additive
non-sensitizer
Known Synonyms
2-Naphthalenecarboxylic acid, 3-hydroxy-4-[(4-methyl-2-sulfophenyl)azo]-, calcium salt (1:1)
Brilliant Carmine 6B
Lithol Rubine BCA
Calcium 3-hydroxy-4-[(4-methyl-2-sulfonatophenyl)diazenyl]naphthalene-2-carboxylate
2-Naphthalenecarboxylic acid, 3-hydroxy-4-[2-(4-methyl-2-sulfophenyl)diazenyl]-, calcium salt (1:1)
D & C Red No. 7
EINECS 226-109-5
3-Hydroxy-4-((2-sulfo-p-tolyl)azo)-2-naphthalenecarboxylic acid, calcium salt (1:1)
UNII-ECW0LZ41X8
Chemical Function
Dye
Pigment
Regulatory Lists
Europe; plastic_additive
Canada; Personal care; Substances in PCP - Canada (4/2014)
pharmaceutical
Personal care
Indirect additives food contact (10/2018)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL2028348
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Lithol Rubine BK / Pigment Rubine
E Number
E180
ADI
1.5 mg/kg bw
Food Category
colorant
Frequently Asked Questions
Is D&C Red No. 7 allowed in the EU?
D&C Red No. 7 EU regulatory status: permitted. Maximum allowed concentration: 0.4% max in non-oxidative hair dyes. This is based on EU Regulation 1223/2009 and its amendments.
What does D&C Red No. 7 do in cosmetics?
D&C Red No. 7 functions as: colorant. It is classified as a Colorant in our database. CAS number: 5281-04-9.
Is D&C Red No. 7 used outside cosmetics?
D&C Red No. 7 also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check D&C Red No. 7 compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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