Is Pigment Red 57:1 safe in cosmetics?
Pigment Red 57:1 has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
EXCELLENT
Cosmetic Ingredient
Pigment Red 57:1
Also known as: 2-Naphthalenecarboxylic acid, 3-hydroxy-4-[(4-methyl-2-sulfophenyl)azo]-, calcium salt (1:1), Brilliant Carmine 6B, Lithol Rubine BCA, Calcium 3-hydroxy-4-[(4-methyl-2-sulfonatophenyl)diazenyl]naphthalene-2-carboxylate, 2-Naphthalenecarboxylic acid, 3-hydroxy-4-[2-(4-methyl-2-sulfophenyl)diazenyl]-, calcium salt (1:1) (+5 more)
INCI: CI 15850:1
Pigment Red 57:1 (CAS 5281-04-9) is a cosmetic cosmetic ingredient functioning as Colorant (calcium salt lake of CI 15850); workhorse red pigment in color. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
Function
Colorant (calcium salt lake of CI 15850); workhorse red pigment in color cosmetics
Editorial assessment
EXCELLENT
Preliminary editorial note — not a computed safety verdict.
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
D&C Red No. 7 — general use including lipstick + external use; not for eye area
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Pigment Red 57:1.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10,000 - 100,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| BR | permitted_colorant | - | Column 3: Not near mucous membranes |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Pigment
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Editorial summary
Preliminary editorial summary for Pigment Red 57:1 — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
colorant
Known Synonyms
2-Naphthalenecarboxylic acid, 3-hydroxy-4-[(4-methyl-2-sulfophenyl)azo]-, calcium salt (1:1)
Brilliant Carmine 6B
Lithol Rubine BCA
Calcium 3-hydroxy-4-[(4-methyl-2-sulfonatophenyl)diazenyl]naphthalene-2-carboxylate
2-Naphthalenecarboxylic acid, 3-hydroxy-4-[2-(4-methyl-2-sulfophenyl)diazenyl]-, calcium salt (1:1)
D & C Red No. 7
EINECS 226-109-5
3-Hydroxy-4-((2-sulfo-p-tolyl)azo)-2-naphthalenecarboxylic acid, calcium salt (1:1)
UNII-ECW0LZ41X8
D&C Red No. 7
Chemical Function
Dye
Pigment
Regulatory Lists
Europe; plastic_additive
Canada; Personal care; Substances in PCP - Canada (4/2014)
pharmaceutical
Personal care
Indirect additives food contact (10/2018)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL2028348
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Lithol Rubine BK / Pigment Rubine
E Number
E180
ADI
1.5 mg/kg bw
Food Category
colorant
Frequently Asked Questions
Is Pigment Red 57:1 allowed in the EU?
Pigment Red 57:1 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Pigment Red 57:1 do in cosmetics?
Pigment Red 57:1 functions as: Colorant (calcium salt lake of CI 15850); workhorse red pigment in color cosmetics. It is classified as a cosmetic ingredient in our database. CAS number: 5281-04-9.
Is Pigment Red 57:1 used outside cosmetics?
Pigment Red 57:1 also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Pigment Red 57:1 compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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D&C Red No. 7
GOOD
Chemical family
colorant
D&C Red No. 7 (CI 15850
POOR
Chemical family
Colorant
PIMENTA OFFICINALIS FRUIT OIL
GOOD
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