Moderate Cosmetic Ingredient NOAEL Data GHS Classified

Decane

INCI: DECANE

CAS Number
124-18-5
Function
Emollient / Solvent
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Allowed. No specific prohibitions. Commonly used as a cosmetic solvent and emollient.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

7 study endpoints found for Decane. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL >=1000 mg/kg bw/day oral rat oral REACH
NOAEL >=5000 mg/kg bw/day oral rat oral REACH
NOAEL >=5000 mg/kg bw/day oral - oral REACH
NOAEL >=900 ppm 1995 rat inhalation REACH
NOAEL >=900 ppm inhalation - inhalation REACH
NOAEL >=1800 2285 1995 rat inhalation REACH
NOAEL >=1800 2285 inhalation - inhalation REACH

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects
If this liquid is swallowed, aspiration into the lungs may result in chemical pneumonitis.
Long-term Exposure Effects
The substance defats the skin, which may cause dryness or cracking.
Routes of Exposure
The substance can be absorbed into the body by inhalation and by ingestion.

Expert Verdict

Low systemic toxicity as a straight-chain alkane. Potential for mild skin defatting with prolonged exposure. Generally considered non-sensitizing and non-irritating at typical cosmetic use levels.. A C10 straight-chain alkane (C₁₀H₂₂). Lightweight, non-greasy feel. Often used as a volatile emollient or carrier solvent in cosmetic formulations. Non-polar hydrocarbon.

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Concern Level: High

Regulatory Flags

potential-allergen ifra_fragrance

Frequently Asked Questions

Is Decane safe in cosmetics?

Low systemic toxicity as a straight-chain alkane. Potential for mild skin defatting with prolonged exposure. Generally considered non-sensitizing and non-irritating at typical cosmetic use levels.. A C10 straight-chain alkane (C₁₀H₂₂). Lightweight, non-greasy feel. Often used as a volatile emollient or carrier solvent in cosmetic formulations. Non-polar hydrocarbon. The EU classifies Decane as "permitted". Safety rating: MODERATE. 7 toxicological study endpoint(s) are available in our database.

Is Decane allowed in the EU?

Decane EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Decane do in cosmetics?

Decane functions as: Emollient / Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 124-18-5.

What is the Margin of Safety for Decane?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Decane?

The NOAEL (No Observed Adverse Effect Level) for Decane is >=1000 mg/kg bw/day based on a oral study via oral route in rat. A total of 7 study endpoints are available. Source: REACH.

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