Good Surfactant NOAEL Data Sensitization Data Dermal Penetration

Decyl Glucoside

INCI: DECYL GLUCOSIDE

CAS Number
68515-73-1
Function
Surfactant; cleanser; wetting agent; co-emulsifier
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes FDA VCRP: listed in 492 cosmetic formulations (rinse-off predominant). No 21 CFR restrictions. Not a sunscreen active. Manufacturer responsible for safety substantiation under FD&C Act. NACDG patch test standard series includes DG since 2009.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

2 study endpoints found for Decyl Glucoside. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
LOEL 500 mg/kg bw/day oral rat oral REACH
LOEL 500 mg/kg bw/day oral rat oral REACH

Sensitization Profile

Contact sensitization data for Decyl Glucoside based on clinical patch test studies and IFRA standards.

Sensitization Rate
low
Allergen Class
surfactant
EU Allergen Listed
no
Patch Test Positive Rate
0.5%
Cross-reactivity Group
glucoside-group
Reaction Type
contact-dermatitis

Source: NACDG; IVDK; ESSCA

Dermal Penetration Profile

Skin absorption and penetration characteristics of Decyl Glucoside, relevant to systemic exposure and MoS calculations.

Absorption %
3-8%
Penetration Level
surface
Penetration Depth
stratum corneum
Molecular Weight
320.4 Da
Log P
1.2
Systemic Absorption
minimal
Topical Bioavailability
2-6%
Safety Margin Factor
low
Vehicle Dependent
Yes — absorption varies by formulation

Source: CIR

Expert Verdict

CIR 2013: safe as used when formulated to be non-irritating. EU Reg 1223/2009: permitted, no Annex restrictions, not CMR, not SVHC. COSMOS/ECOCERT compliant. Dermal absorption <0.01%. Genotoxicity negative. Emerging allergen with 0.65-2.0% sensitization in patch-test populations.

⚠️
Concern Level: Low

Regulatory Flags

emerging-allergen eye-irritant cross-reactive patch-test-inclusion rinse-off-max-33pct leave-on-max-5pct cosmos-approved no-eu-restriction ph-adjustment-required epa_safer_alternative

Frequently Asked Questions

Is Decyl Glucoside safe in cosmetics?

CIR 2013: safe as used when formulated to be non-irritating. EU Reg 1223/2009: permitted, no Annex restrictions, not CMR, not SVHC. COSMOS/ECOCERT compliant. Dermal absorption <0.01%. Genotoxicity negative. Emerging allergen with 0.65-2.0% sensitization in patch-test populations. The EU classifies Decyl Glucoside as "permitted". Safety rating: GOOD. 2 toxicological study endpoint(s) are available in our database.

Is Decyl Glucoside allowed in the EU?

Decyl Glucoside EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Decyl Glucoside do in cosmetics?

Decyl Glucoside functions as: Surfactant; cleanser; wetting agent; co-emulsifier. It is classified as a Surfactant in our database. CAS number: 68515-73-1.

What is the Margin of Safety for Decyl Glucoside?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Decyl Glucoside?

The NOAEL (No Observed Adverse Effect Level) for Decyl Glucoside is 500 mg/kg bw/day based on a oral study via oral route in rat. A total of 2 study endpoints are available. Source: REACH.

Compliance Tools

Check Decyl Glucoside compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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