Is Dextran safe in cosmetics?
Dextran has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
Dextran
Also known as: Dextran 40,70,110, Dextranum 40,70, EINECS 232-677-5, Low molecular dextran-L, Polyglucinum (+15 more)
INCI: DEXTRAN
Dextran (CAS 9004-54-0) is a cosmetic cosmetic ingredient functioning as Binding, Viscosity Controlling. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in food safety data.
View industrial chemical safety profile for CAS 9004-54-0 →
Auto-generated CPSR Part A draft with source citations
Function
Binding, Viscosity Controlling
Safety Rating
EXCELLENT
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
GRAS as indirect food additive; Dextran 70 approved OTC ophthalmic demulcent at 0.1%; no cosmetic restrictions. CIR concluded safe in present practices of use and concentration.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Dextran.
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
KeratinoSens IC50
2000 µM
GHS: inconclusive
Source: KS: Urbisch et al. 2015 [DOI:10.1016/j.yrtph.2014.12.008]
Additional Ingredient Properties
2 property records from structured ingredient metadata.
polymer
{"cas_number": "9004-54-0", "ingredient_class": "film_former/moisture_retention", "polymer_type": "natural_polysaccharide", "chemical_backbone": "other", "molecular_weight_Da_range": "10000-2000000", "ionic_character": "nonionic", "pH_viscosity_sensitivity": "moderate", "salt_tolerance": "moderate", "electrolyte_effect_on_viscosity": "moderate", "temperature_viscosity_sensitivity": "moderate", "fi…
supply_chain
{"primary_producing_countries": "France, Germany, USA", "secondary_producing_countries": "China, Japan, Netherlands", "raw_material_origin": "microbial", "agricultural_crop_or_wild_harvested": "fermentation", "cultivation_climate_required": "bacterial", "harvest_season": "continuous", "annual_global_production_tonnes": "28000", "market_share_top_producer_pct": "62", "supply_chain_length": "1_inter…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Binder
Filler
Processing aids not otherwise specified
Surface modifier
Thickening agent
Viscosity modifier
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Dextran.
Regulatory Flags
cir-safe
no-sccs-opinion
no-eu-max
gras-fda
high-mw-polymer
fda_food_additive
Known Synonyms
Dextran 40,70,110
Dextranum 40,70
EINECS 232-677-5
Low molecular dextran-L
Polyglucinum
Dextranum
UNII-7SA290YK68
UNII-K3R6ZDH4DU
UNII-ZNJ8R24I7Z
UNII-65DL069QBP
UNII-21C3YS80Q6
UNII-42N66Q2197
UNII-PD6VU01UVN
UNII-V7031C06AY
UNII-E8A73H7RG1
UNII-05Q25F6XJ3
UNII-P8272ET3N5
UNII-41Z0077J45
UNII-7C8S056150
UNII-B854H05S7D
Chemical Function
Viscosity modifier
Binder
Filler
Processing aids not otherwise specified
Thickening agent
Surface modifier
Regulatory Lists
Canada; consumer_product; Substances in Products - Canada (4/2014)
Canada; consumer_product; Substances in Products - Canada (4/2014)
pharmaceutical
Canada; pharmaceutical
Canada; pharmaceutical
pharmaceutical
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in food safety data.
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
DEXTRANS (AVG M W LESS THAN 100,000)
Food Category
thickener
Frequently Asked Questions
Is Dextran allowed in the EU?
Dextran EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dextran do in cosmetics?
Dextran functions as: Binding, Viscosity Controlling. It is classified as a cosmetic ingredient in our database. CAS number: 9004-54-0.
Is Dextran used outside cosmetics?
Dextran also appears in food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Dextran compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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