Regulatory Status
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Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
CIR Expert Panel determined insufficient data to support safety in cosmetics; needed studies include concentration limits, impurity profile, UV absorption, 28-day dermal toxicity, skin penetration, dermal irritation and sensitization testing, and genotoxicity assays; cytotoxic and genotoxic effects reported at high doses; hydroquinone moiety raises concerns for depigmentation and oxidative damage; rarely used in finished products.
Regulatory Flags
Frequently Asked Questions
Is Di-t-Butylhydroquinone (DTBHQ) safe in cosmetics?
CIR Expert Panel determined insufficient data to support safety in cosmetics; needed studies include concentration limits, impurity profile, UV absorption, 28-day dermal toxicity, skin penetration, dermal irritation and sensitization testing, and genotoxicity assays; cytotoxic and genotoxic effects reported at high doses; hydroquinone moiety raises concerns for depigmentation and oxidative damage; rarely used in finished products. The EU classifies Di-t-Butylhydroquinone (DTBHQ) as "permitted". Safety rating: POOR.
Is Di-t-Butylhydroquinone (DTBHQ) allowed in the EU?
Di-t-Butylhydroquinone (DTBHQ) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Di-t-Butylhydroquinone (DTBHQ) do in cosmetics?
Di-t-Butylhydroquinone (DTBHQ) functions as: Antioxidant (lipid peroxidation inhibitor). It is classified as a cosmetic ingredient in our database. CAS number: 1322-72-1 (mixture); 88-58-4 (2,5-isomer).
What is the Margin of Safety for Di-t-Butylhydroquinone (DTBHQ)?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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