Is Diammonium Citrate safe in cosmetics?
Diammonium Citrate has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
Diammonium Citrate
Also known as: Ammonium monohydrogen citrate, Citric acid, diammonium salt, Diammonium 2-hydroxy-1,2,3-propanetricarboxylate, Dibasic ammonium citrate, EINECS 221-146-3 (+3 more)
INCI: DIAMMONIUM CITRATE
Diammonium Citrate (CAS 3012-65-5) is a cosmetic cosmetic ingredient functioning as Buffering, chelating. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 3012-65-5 →
Auto-generated CPSR Part A draft with source citations
Function
Buffering, chelating
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
diazanium;3-carboxy-3-hydroxypentanedioate
InChIKey
YXVFQADLFFNVDS-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — citric acid and salts are FDA GRAS (21 CFR 184.1033 for citric acid); CIR reviewed safe
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Diammonium Citrate.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Skin Eye Respiratory Irritation
Dust: irritating to eyes, nose and throat; if inhaled will cause coughing or difficult breathing. Solid: irritating to skin and eyes.
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Chelating agent
Lubricating agent
pH regulating agent
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Diammonium Citrate.
Regulatory Flags
fda_food_additive
Known Synonyms
Ammonium monohydrogen citrate
Citric acid, diammonium salt
Diammonium 2-hydroxy-1,2,3-propanetricarboxylate
Dibasic ammonium citrate
EINECS 221-146-3
Microstop
Ammonium citrate (2:1)
UNII-N9BUG430K8
Chemical Function
Chelating agent
pH regulating agent
Lubricating agent
Regulatory Lists
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
inert_ingredient; Pesticides
inert_ingredient; non_food_use; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3189066
Frequently Asked Questions
Is Diammonium Citrate allowed in the EU?
Diammonium Citrate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Diammonium Citrate do in cosmetics?
Diammonium Citrate functions as: Buffering, chelating. It is classified as a cosmetic ingredient in our database. CAS number: 3012-65-5.
Is Diammonium Citrate used outside cosmetics?
Diammonium Citrate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Diammonium Citrate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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DIALLYLDIMETHYL AMMONIUM CHLORIDE
Good
Browse nearby
Not Reported
DIBROMOCYANOACETAMIDE
Good
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Antimicrobial
DIBUTYL PHTHALATE
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