Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
5 study endpoints found for Diammonium EDTA. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | >=500 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | >=500 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | >=938 mg/kg bw/day | oral | mouse | oral | REACH |
| NOAEL | 1125 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | >=500 mg/kg bw/day | oral | - | oral | REACH |
Expert Verdict
Diammonium EDTA is a chelating agent permitted in cosmetics with excellent safety profile at typical use levels below 0.5%. Environmental consideration: poorly biodegradable with potential to remobilize heavy metals in wastewater; weak in vitro mutagenicity signals not relevant at cosmetic use concentrations.
Frequently Asked Questions
Is Diammonium EDTA safe in cosmetics?
Diammonium EDTA is a chelating agent permitted in cosmetics with excellent safety profile at typical use levels below 0.5%. Environmental consideration: poorly biodegradable with potential to remobilize heavy metals in wastewater; weak in vitro mutagenicity signals not relevant at cosmetic use concentrations. The EU classifies Diammonium EDTA as "permitted". Safety rating: EXCELLENT. 5 toxicological study endpoint(s) are available in our database.
Is Diammonium EDTA allowed in the EU?
Diammonium EDTA EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Diammonium EDTA do in cosmetics?
Diammonium EDTA functions as: Chelating agent. It is classified as a cosmetic ingredient in our database. CAS number: 20824-56-0.
What is the Margin of Safety for Diammonium EDTA?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Diammonium EDTA?
The NOAEL (No Observed Adverse Effect Level) for Diammonium EDTA is >=500 mg/kg bw/day based on a oral study via oral route in rat. A total of 5 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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