Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Dihydroxybiphenyl. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOEL | 8 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 125 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
GHS07: harmful in contact with skin (H312), causes skin irritation (H315), serious eye irritation (H319), respiratory irritation (H335). No SCCS opinion. No CIR review. Not a typical cosmetic ingredient—treat with extreme caution if formulating.
Frequently Asked Questions
Is Dihydroxybiphenyl safe in cosmetics?
GHS07: harmful in contact with skin (H312), causes skin irritation (H315), serious eye irritation (H319), respiratory irritation (H335). No SCCS opinion. No CIR review. Not a typical cosmetic ingredient—treat with extreme caution if formulating. The EU classifies Dihydroxybiphenyl as "permitted". Safety rating: POOR. 2 toxicological study endpoint(s) are available in our database.
Is Dihydroxybiphenyl allowed in the EU?
Dihydroxybiphenyl EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dihydroxybiphenyl do in cosmetics?
Dihydroxybiphenyl functions as: Antioxidant / stabilizer (primarily industrial; rare cosmetic use). It is classified as a cosmetic ingredient in our database. CAS number: 92-88-6.
What is the Margin of Safety for Dihydroxybiphenyl?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Dihydroxybiphenyl?
The NOAEL (No Observed Adverse Effect Level) for Dihydroxybiphenyl is 8 mg/kg bw/day based on a oral study via oral route in rat. A total of 2 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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