Excellent Cosmetic Ingredient NOAEL Data

Diisopropyl Adipate

INCI: DIISOPROPYL ADIPATE

CAS Number
6938-94-9
Function
Emollient, skin conditioning agent, solvent, plasticizer with quick absorption
Safety Rating
EXCELLENT

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes No FDA-specific restrictions for cosmetic use.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for Diisopropyl Adipate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 1000 mg/kg bw/day oral rat oral REACH

Expert Verdict

Safe for cosmetic use with low acute toxicity and no sensitization observed in human testing at concentrations up to 20%.

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Concern Level: None

Regulatory Flags

ifra_fragrance fda_food_additive jecfa_safe

Frequently Asked Questions

Is Diisopropyl Adipate safe in cosmetics?

Safe for cosmetic use with low acute toxicity and no sensitization observed in human testing at concentrations up to 20%. The EU classifies Diisopropyl Adipate as "permitted". Safety rating: EXCELLENT. 1 toxicological study endpoint(s) are available in our database.

Is Diisopropyl Adipate allowed in the EU?

Diisopropyl Adipate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Diisopropyl Adipate do in cosmetics?

Diisopropyl Adipate functions as: Emollient, skin conditioning agent, solvent, plasticizer with quick absorption. It is classified as a cosmetic ingredient in our database. CAS number: 6938-94-9.

What is the Margin of Safety for Diisopropyl Adipate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Diisopropyl Adipate?

The NOAEL (No Observed Adverse Effect Level) for Diisopropyl Adipate is 1000 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.

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