Is Diisopropyl Adipate safe in cosmetics?
Diisopropyl Adipate has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
Diisopropyl Adipate
Also known as: Hexanedioic acid, bis(1-methylethyl) ester, beta dia, BRN 1785346, EINECS 230-072-0, Iso-adipate 2/043700 (+4 more)
INCI: DIISOPROPYL ADIPATE
Diisopropyl Adipate (CAS 6938-94-9) is a cosmetic cosmetic ingredient functioning as Emollient, skin conditioning agent, solvent, plasticizer with quick absorption. NOAEL 1000 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 6938-94-9 →
Auto-generated CPSR Part A draft with source citations
Function
Emollient, skin conditioning agent, solvent, plasticizer with quick absorption
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
dipropan-2-yl hexanedioate
InChIKey
ZDQWESQEGGJUCH-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No FDA-specific restrictions for cosmetic use.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Diisopropyl Adipate.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Diisopropyl Adipate across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| BR | banned | - | - |
Additional Ingredient Properties
3 property records from structured ingredient metadata.
comedogenicity_detail
{"comedogenicity_rating": "1", "irritancy_rating": "0", "skin_type_suitability": "all,oily,combination,normal,acne-prone", "acne_safe": "yes", "source": "Light ester"}
lipid
{"cas_number": "6938-94-9", "lipid_class": "ester", "botanical_source": "synthetic/derived", "plant_part": "derived", "extraction_method": "refined", "fatty_acid_profile_main_pct": "adipic ester", "omega_classification": "saturated", "comedogenicity_rating_0_5": "1", "absorption_rate": "fast", "skin_feel": "dry", "spreadability": "excellent", "emollient_grade": "A_excellent", "primary_application"…
solubility_hlb
{"water_soluble": "no", "oil_soluble": "yes", "hlb_required": "5.0", "soluble_in": "oils, ethanol", "insoluble_in": "water, glycerin, propylene glycol", "log_p": "3.9", "appearance": "clear liquid", "source": "Hallstar"}
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
1966
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
DIISOPROPYL ADIPATE | 2010 | No safety concern at current levels of intake when used as a flavouring agent | TRS 960-JECFA 73/71
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Anti-adhesive/cohesive
Deodorizer
Flavouring and nutrient
Fragrance
Lubricating agent
Plasticizer
Softener and conditioner
Solvent
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Diisopropyl Adipate.
Regulatory Flags
ifra_fragrance
fda_food_additive
jecfa_safe
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Diisopropyl Adipate by CAS number or substance name.
Studies
33
Lowest NOAEL
119.89 mg/kg bw/day
Highest NOAEL
2187 mg/kg bw/day
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
Hexanedioic acid, bis(1-methylethyl) ester
beta dia
BRN 1785346
EINECS 230-072-0
Iso-adipate 2/043700
Prodipate
Tegester 504-D
UNII-P7E6YFV72X
Diisopropyl adipat
Chemical Function
Solvent
Softener and conditioner
Plasticizer
Deodorizer
Fragrance
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3184058
Frequently Asked Questions
Is Diisopropyl Adipate allowed in the EU?
Diisopropyl Adipate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Diisopropyl Adipate do in cosmetics?
Diisopropyl Adipate functions as: Emollient, skin conditioning agent, solvent, plasticizer with quick absorption. It is classified as a cosmetic ingredient in our database. CAS number: 6938-94-9.
Is Diisopropyl Adipate used outside cosmetics?
Diisopropyl Adipate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Diisopropyl Adipate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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