Is Disodium Fumarate safe in cosmetics?
Disodium Fumarate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Disodium Fumarate
Also known as: 2-Butenedioic acid (2E)-, sodium salt (1:2), 2-Butenedioic acid (2E)-, disodium salt, 2-Butenedioic acid (E)-, disodium salt, Fumarate de disodium, Dinatriumfumarat (+9 more)
INCI: DISODIUM FUMARATE
Disodium Fumarate (CAS 17013-01-3) is a cosmetic cosmetic ingredient functioning as Skin conditioning; buffering agent (salt of fumaric acid). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 17013-01-3 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning; buffering agent (salt of fumaric acid)
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
disodium;(E)-but-2-enedioate
InChIKey
MSJMDZAOKORVFC-SEPHDYHBSA-L
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted – fumaric acid is GRAS (21 CFR 172.350); CIR concluded safe as used in cosmetics
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Disodium Fumarate.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
pH regulating agent
Expert Verdict
Expert safety assessment and concern-level summary for Disodium Fumarate.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Disodium Fumarate by CAS number or substance name.
Studies
4
Lowest NOAEL
2080 mg/kg bw/day
Highest NOAEL
2080 mg/kg bw/day
CIR Safety Assessment
Known Synonyms
2-Butenedioic acid (2E)-, sodium salt (1:2)
2-Butenedioic acid (2E)-, disodium salt
2-Butenedioic acid (E)-, disodium salt
Fumarate de disodium
Dinatriumfumarat
fumarato de disodio
Fumaric acid disodium salt
FUMARATE, DISODIUM
EINECS 241-087-7
Fumaran sodny
UNII-0578QTK490
E365
Fumaric acid, disodium salt
Sodium fumarate
Chemical Function
pH regulating agent
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA count match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Adverse Event Associations
49
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Sodium fumarate
E Number
E365
ADI
6 mg/kg bw
Food Category
preservative
Frequently Asked Questions
Is Disodium Fumarate allowed in the EU?
Disodium Fumarate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Disodium Fumarate do in cosmetics?
Disodium Fumarate functions as: Skin conditioning; buffering agent (salt of fumaric acid). It is classified as a cosmetic ingredient in our database. CAS number: 17013-01-3.
Is Disodium Fumarate used outside cosmetics?
Disodium Fumarate also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Disodium Fumarate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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(AGARICUS BLAZEI FERMENT + GANODERMA LUCIDUM FERMENT + GANODERMA MULTIPILEUM FERMENT) EXTRACT
Good
Similar safety
Anti-sebum, Antioxidant, Skin Protecting
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA) ROOT/CNIDIUM OFFICINALE RHIZOME EXTRACT
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Skin Conditioning, Skin Conditioning ...
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA/SCUTELLARIA BAICALENSIS) ROOT/(CNIDIUM OFFICINALE/COPTIS CHINENSIS) RHIZOME/GARDENIA JASMINOIDES FRUIT/PHELLODENDRON CHINENSE BARK EXTRACT
Good
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(ANGELICA GIGAS/GLYCYRRHIZA URALENSIS/REHMANNIA GLUTINOSA ROOT)/ANGELICA GIGAS STEM/CARTHAMUS TINCTORIUS FLOWER/(CARTHAMUS TINCTORIUS/PRUNUS PERSICA SEED)PORIA COCOS WATER
Good
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Humectant, Skin Conditioning, Skin Pr...
(ANGELICA KEISKEI/CHRYSANTHEMUM ZAWADSKII) LEAF/STEM/CINNAMOMUM CASSIA BARK/TRICHOSANTES KIRILOWII FRUIT/ULMUS DAVIDIANA BARK/ROOT/(PAEONIA JAPONICA/BUPLEURUM FALCATUM/POLYGALA TENUIFOLIA ROOT)/VISCUS ALBUM STEM EXTRACT
Good
Similar safety
Anti-seborrheic, Anti-sebum, Antioxid...
(APPLE/CITRUS JUNOS/LENTIL/PEAR/PUMPKIN/STRAWBERRY/TOMATO FRUIT)/CORN KERNEL/(ARCTIUM LAPPA/BRASSICA OLERACEA ACEPHALA/CABBAGE/CAMELLIA SINENSIS/MORINGA OLEIFERA/RADISH/SPINACH LEAF)/(SORGHUM BICOLOR LEAF/STEM)/OAT MEAL/POTATO PULP/(CARROT/NELUMBO NUCIFERA/RADISH/WILD YAM ROOT)/(AMARANTHUS HYPOCHONDRIACUS/CASHEW/CICER ARIETINUM/COIX LACRYMA-JOBI MA-YUEN /MACADAMIA TERNIFOLIA/PHASEOLUS ANGULARIS/PISTACIA VERA/RHYNCHOSIA NULUBILIS/RICE/SESAME/SETARIA ITALICA/SOYBEAN/SWEET ALMOND/WHEAT SEED)/HORDEUM VULGARE SPROUT/CYPERUS ESCULENTUS TUBER/ARTEMISIA PRINCEPS/BROCCOLI/CHENOPODIUM QUINOA/ENTEROMORPHA COMPRESSA/HORDEUM VULGARE/IPOMOEA BATATAS/LAMINARIA JAPONICA/LENTINUS EDODES/PLEUROTUS OSTREATUS/PORPHYRA TENERA/UNDARIA PINNATIFIDA EXTRACT
Good
Similar safety
Antioxidant
Sodium Fumarate
Good
Chemical family
Skin conditioning, buffering agent
DISODIUM GLUCARATE/GLUCONATE/GLUCURONATE/GLYCOLATE/KETOGLUCONATE/OXALATE/TARTRATE/TARTRONATE
Good
Browse nearby
Chelating
DISODIUM SELENITE
Moderate
Browse nearby
Not Reported
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